Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives
AssigneeUniversity of Florida Research Foundation, Inc.
InventorRaymond J. Bergeron
Life of this patent
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Abstract
A polyamine and pharmaceutical composition containing an effective amount of the polyamine useful for administration to a human or non-human animal afflicted with neoplastic cells, the polyamine having the formula: R.sub.1 --NH--(CH.sub.2).sub.3 --NH--(CH.sub.2).sub.3 --NH--(CH.sub.2).sub.3 --NH--R.sub.2 wherein R.sub.1 and R.sub.2 are both ethyl; or a salt thereof with a pharmaceutically acceptable acid, as well as a method of treatment comprising administering to such animals an effective amount of a polyamine of the above formula wherein R.sub.1 and R.sub.2 are each lower alkyl of 1-4 carbon atoms.
Claims4
A compound of the formula:
- R.sub.1 --NH--(CH.sub.2).sub.3 --NH--(CH.sub.2).sub.3 --NH--(CH.sub.2).sub.3 --NH-R.sub.2
- wherein R.sub.1 and R.sub.2 are both ethyl;
- or a salt thereof with a pharmaceutically acceptable acid.
A pharmaceutical composition useful for administration to a human or non-human animal afflicted with neoplastic cells sensitive to a compound of the formula:
- R.sub.1 --NH--(CH.sub.2).sub.3 --NH--(CH.sub.2).sub.3 --NH--(CH.sub.2).sub.3 --NH--R.sub.2
- wherein R.sub.1 and R.sub.2 are both ethyl;
- or a salt thereof with a pharmaceutically acceptable acid, comprising a therapeutically anti-neoplastic effective amount of said compound and a pharmaceutically acceptable carrier therefor.
A method for treating a human or non-human animal afflicted with neoplastic cells sensitive to a compound of the formula:
- R.sub.1 --NH--(CH.sub.2).sub.3 --NH--(CH.sub.2).sub.3 --NH--(CH.sub.2).sub.3 --NH--R.sub.2
- wherein:
- R.sub.1 and R.sub.2 may be the same or different and are lower alkyl of 1-4 carbon atoms;
- or a salt thereof with a pharmaceutically acceptable acid, comprising administering to said animal an anti-neoplastic effective amount of said compound.
Dependencies are inferred from the claim text.