Substituted benzoylguanidines, process for their preparation, their use as a pharmaceutical as inhibitors of the cellular NA+/H+ exchange or as a diagnostic, and pharmaceutical containing them

A benzoylguanidine of the formula I ##STR6## in which:

• one of the substituents R(1), R(2) and R(3) is N.sub.3, CN, OH or (C.sub.1 -C.sub.10)-alkyloxy, if at least one of the remaining substituents R(1), R(2) or (R3) is an alkyl radical having 3 to 12 carbon atoms, or
• one of the substituents R(1), R(2) or R(3) is
• R(4)--C.sub.n H.sub.2n --O.sub.m where
• m is zero or 1,
• n is zero, 1, 2 or 3,
• R(4) is C.sub.p F.sub.2p+1
• where p is 1, 2 or 3 if n is zero or 1, or
• R(4) is (C.sub.3 -C.sub.12)-cycloalkyl, phenyl, or phenyl substituted by a substituent selected from the group consisting of F, Cl, CF.sub.3, methyl, methoxy or NR(5)R(6), where R(5) and R(6) are hydrogen and (C.sub.1 -C.sub.4)-alkyl, or
• one of the substituents R(1), R(2) or R(3) is --C.ident.CR(5), --C.dbd.CR(5),
• R(5) is phenyl
• which is unsubstituted or substituted by 1-3 substituents selected from the group consisting of F, Cl, CF.sub.3, methyl, methoxy, hydroxyl, amino, methylamino and dimethylamino, or
• R(5) is (C.sub.1 -C.sub.6)-alkyl,
• which is unsubstituted or substituted by 1-3 OH, or
• R(5) is (C.sub.3 -C.sub.8)-cycloalkyl,
• R(6) is hydrogen or methyl,
• or R(1), R(2), and R(3) are hydrogen, F, Cl, Br, I, or (C.sub.1 -C.sub.12) alkyl;
• and the pharmacologically acceptable salts thereof, with the exception of the compounds benzoylguanidine, 4-chlorobenzoylguanidine, 3,4-dichlorobenzoylguanidine and 3- or 4-methylbenzoylguanidine.