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AssigneeBoard of Supervisors of Louisiana State University and Agricultural and Mechanical College
InventorsAnthony H. Cincotta, Albert H. Meier
Estimating the term…
A process for the long term modification and regulation of lipid and carbohydrate metabolism--generally to reduce obesity, insulin resistance, and hyperinsulinemia or hyperglycemia, or both (these are the hallmarks of noninsulin dependent, or Type II diabetes)--by administration (i.e., by oral, sublingual or parenternal administration) to a vertebrate, animal or human, of a dopamine agonist, e.g., bromocriptine. Administration of the bromocriptine is made over a limited period at a time of day dependent on the normal circadian rhythm of insulin resistant and insulin sensitive members of a similar species. Insulin resistance, and hyperinsulinemia and hyperglycemia, or both, can be controlled in humans on a long term basis by such treatment inasmuch as the short term, daily administration resets hormonal timing in the neural centers of the brain to produce long term effects.
A process for the therapeutic modification and regulation of lipid metabolism in an animal, or human subject, which comprises administering to a subject in need of treatment, on a timed daily basis a dopamine agonist in dosage amount and for a period sufficient to reduce plasma triglyceride levels in said animal or human subject.
A process for the modification and regulation of lipid metabolism in a human subject in need of treatment which comprises administering to the subject, over a period ranging from about 30 days to about 120 days, at levels ranging from about 3 micrograms to about 40 micrograms, per pound of body weight, daily doses of a dopamine agonist at from about 1 to about 10 hours after the normal time of day that the prolactin level is at its peak-in a lean insulin-sensitive subject of the same species and sex, to produce a change of the neuroendocrine system of the subject to mimic that of the lean subject such that plasma triglyceride levels are reduced in said subject in need of treatment.
In a method for treating a vertebrate exhibiting one or more of obesity, insulin resistance, hyperinsulinemia, glucose intolerance, or hyperglycemia by delivery to said vertebrate of a prolactin inhibitor, the improvement which comprises:
A method for treating an animal exhibiting one or more of obesity, insulin resistance, hyperinsulinemia, glucose intolerance, or hyperglycemia, comprising:
A method for modifying or regulating glucose metabolism in an animal or human subject in need of such treatment comprising:
Dependencies are inferred from the claim text.