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AssigneeMeso Scale Technology LLP
InventorsRichard J. Massey, Mark T. Martin, Liwen Dong, Ming Lu, Alan Fischer, Fabian Jameison, Pam Liang, Robert Hoch, Jonathan K. Leland
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Graphitic nanotubes, which include tubular fullerenes (commonly called "buckytubes") and fibrils, which are functionalized by chemical substitution, are used as solid supports in electrogenerated chemiluminescence assays. The graphitic nanotubes are chemically modified with functional group biomolecules prior to use in an assay. Association of electrochemiluminescent ruthenium complexes with the functional group biomolecule-modified nanotubes permits detection of molecules including nucleic acids, antigens, enzymes, and enzyme substrates by multiple formats.
A nanotube comprising carbon to which is attached an assay-performance substance, said assay-performance also being linked to a label compound capable of being induced to luminesce.
A composition for the detection of an analyte of interest present in a sample, which composition comprises:
A composition for the detection of an analyte of interest present in a sample, which composition comprises:
A composition for the detection of an analyte of interest present in a sample, which composition comprises
A method for performing a binding assay for an analyte of interest present in a sample comprising the steps of:
A method for performing a binding assay for an analyte of interest present in a sample based upon measurement of electrochemiluminescence at an electrode surface comprising the steps:
A method for performing a binding assay for an analyte of interest present in a sample based upon measurement of electrochemiluminescence at an electrode surface comprising the steps:
A composition of matter for use as a reagent in a microparticulate-based binding assay comprising functionalized graphitic nanotubes bound to an assay-performance-substance and at least one other component selected from the group consisting of:
An assay reagent for an assay based upon a binding reaction and the measurement of an electrochemiluminescent phenomenon comprising:
A method for performing an assay for an analyte of interest present in a sample, which analyte is an enzyme, comprising the steps of:
A graphitic nanotube linked to at least two components selected from the group consisting of (i) an electrochemiluminescent label, (ii) an enzyme and (iii) an enzyme cofactor.
A graphitic nanotube linked to an enzyme biosensor, wherein said enzyme biosensor includes a label compound capable of being induced to electrochemiluminesce.
Dependencies are inferred from the claim text.