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AssigneeKlinikum Der Albert-Ludwigs-Universitat Freiburg
InventorsLothar Kanz, Wolfram Brugger, Reinhard Henschler, Gabriele Kohler, Hans-Eckart Schaefer, Albrecht Lindemann, Roland Mertelsmann, Andreas Mackensen, Paul Fisch, Birgit Herbst
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Dendritic cells are of interest therapeutically as antigen-presenting cells. A process is disclosed in which peripheral blood cells are first isolated and the CD 34 antigen-expressing blood progenitor cells which they contain are then enriched. These enriched cells are expanded ex-vivo using a combination of haematopoietic growth factors and cytokines. Over a period of 10-20 days, they give rise, in particular to dendritic cells which, where appropriate, can be purified still further. These cells are functionally active with regard to the ability to present antigen.
A process for preparing dendritic cells, comprising
A kit useful for preparing dendritic cells, comprising:
A kit for preparing dendritic cells consisting of separate receptacles for each of (1) a hematopoietic growth factor combination consisting of interleukin-1, interleukin-3, interleukin-6, stem cell factor and erythropoietin, and (2) a hematopoietic growth factor combination consisting of interleukin-4 and granulocyte macrophage colony stimulating factor.
Dependencies are inferred from the claim text.