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US 5,866,113 AGranted
Medical device with biomolecule-coated surface graft matrix
AssigneeMedtronic, Inc.
InventorsMarc Hendriks, Michel Verhoeven, Linda L. Cahalan, Patrick T. Cahalan, Benedicte Fouache
Life of this patent
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Abstract
A medical device having a surface graft matrix comprising carboxyl-functional groups located on the device, the surface graft matrix comprising an outer portion; and one or more biomolecules covalently coupled to the surface graft matrix, wherein a majority of the biomolecules are located in the outer portion of the surface graft matrix. The surface graft matrix can also be loaded with a pharmaceutical agent.
Claims20
A medical device comprising:
- a) a polymerized surface graft matrix comprising carboxyl-functional groups located on the device, the polymerized surface graft matrix comprising an outer portion;
- and
- b) one or more biomolecules covalently coupled to the polymerized surface graft matrix, wherein a majority of the biomolecules are located in the outer portion of the polymerized surface graft matrix.
A medical device comprising:
- a) a polymerized surface graft matrix comprising carboxyl-functional groups located on the device, the polymerized surface graft matrix comprising an outer portion;
- b) one or more linker molecules covalently coupled to the polymerized surface graft matrix, wherein a majority of the linker molecules are located in the outer portion of the polymerized surface graft matrix;
- and
- c) one or more biomolecules covalently coupled to the linker molecules.
1 more element
Dependencies are inferred from the claim text.