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US 5,863,627 AGranted
Hydrolytically-and proteolytically-stable polycarbonate polyurethane silicone copolymers
AssigneeCardioTech International, Inc.
InventorsMichael Szycher, Donald Dempsey, Alan Edwards
Life of this patent
Estimating the term…
Abstract
A biocompatible, biodurable polycarbonate polyurethane with internal polysiloxane segments and devices made therefrom.
Claims35
A biodurable polycarbonate polyurethane block copolymer comprising
- (a) a polycarbonate glycol internal segment;
- (b) a polyurethane internal segment;
- (c) a polydialkylsiloxane internal segment;
- (d) di(C.sub.1-6 alkyl)amino or C.sub.1-6 hydroxyalkyl terminating segments;
- (e) cyclo(C.sub.5-7 alkane)diamino internal segments;
- and
- (f) C.sub.2-4 alkylene diamino internal segments;
- wherein said segments are linked by urethane, urea, and C--Si--C moieties, said block copolymer being devoid of hydrolytically unstable Si--O--C linkages and being substantially devoid of ether linkages.
5 more elements
A biodurable polycarbonate polyurethane block copolymer, obtained from reactants comprising
- (a) an aromatic or aliphatic diisocyanate;
- (b) a polycarbonate diol;
- (c) a difunctional polydialkylsiloxane having a viscosity between 15 and 70 centistokes;
- (d) two chain extenders independently selected from C.sub.2-8 diamines and C.sub.2-8 diols, wherein said diamines and diols are cyclic, straight chain, or branched, and at least one chain extender is cyclic or branched;
- and
- (e) a C.sub.2-6 alkanol or di(C.sub.2-6 alkyl) amine chain terminator, or mixture thereof;
- wherein said block copolymer is devoid of hydrolytically unstable Si--O--C linkages and substantially devoid of ether linkages.
4 more elements
A vascular graft comprising a graft wall base including at least 85% by weight a biodurable polycarbonate polyurethane block copolymer comprising
- (a) a polycarbonate glycol internal segment;
- (b) a polyurethane internal segment;
- (c) a polydialkylsiloxane internal segment;
- (d) di(C.sub.1-6 alkyl)amino or C.sub.1-6 hydroxyalkyl terminating segments;
- (e) cyclo(C.sub.5-7 alkane)diamino or cyclo(C.sub.5-7 alkane)dihydroxy internal segments;
- and
- (f) C.sub.2-8 alkylene diamino or dihydroxy internal segments;
- wherein said segments are linked by urethane, urea, and C--Si--C moieties, said block copolymer being devoid of hydrolytically unstable Si--O--C linkages and being substantially devoid of ether linkages;
- said graft wall being an anisotropically microporous single layer with a porosity between 60% and 80% void/volume.
6 more elements
A method of making a vascular graft, said method comprising
- (a) obtaining a polymer solution comprising
- a polar solvent;
- a water soluble filler, 10% to 60% by weight;
- a surfactant 1% to 10% by weight;
- and
- a polycarbonate polyurethane block copolymer obtained from reactants comprising
- (i) an aromatic or aliphatic diisocyanate;
- (ii) a polycarbonate diol;
- (iii) a difunctional polydialkylsiloxane or polydi(fluoroalkyl)siloxane having a viscosity between 15 and 70 centistokes;
- (iv) two chain extenders independently selected from C.sub.2-7 diamines and C.sub.2-8 diols, wherein said diamines and diols are cyclic, straight chain, or branched, and at least one chain extender is cyclic or branched;
- and
- (v) a C.sub.2-6 alkanol or di(C.sub.2-6 alkyl) amine chain terminator, or mixture thereof;
- wherein said block copolymer is devoid of hydrolytically unstable Si--O--C linkages and substantially devoid of ether linkages;
- (b) contacting said polymer solution with a mandrel surface;
- (c) synchronously rotating said mandrel and an extrusion head;
- (d) drawing said mandrel through an extrusion head into a coagulant maintained at a temperature less than 55 degrees Centigrade (preferably 40 degrees Centigrade);
- and
14 more elements
Dependencies are inferred from the claim text.