# US 5,863,552 A · Method of treating myofascial pain syndrome with relaxin

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- Number: US 5,863,552 A
- Document ID: US5863552A
- Status: Granted
- Kind: A
- Filed: 1998-01-09
- Granted: 1999-01-26
- Earliest claimed: 1995-11-17
- Inventors: Samuel K. Yue
- Web page: https://patentgrep.com/patent/US5863552A

## CPC

- A61K 38/2221: {Relaxins}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

A method of treating involuntary muscle dysfunctions includes administering a therapeuticaly effective amount of relaxin to a patient. Involuntary muscle dysfunctions amenable to treatment with relaxin include fibromyalgia, myofascial pain syndrome, chronic fatigue syndrome, dystonia, pelvic floor dysfunction, irritable bowel syndrome, and others.

## Claims

### Claim 1

A method for treating myofascial pain syndrome by administering to a patient exhibiting painful contraction of muscles from myofascial pain syndrome a therapeutically effective amount of relaxin hormone, thereby decreasing the amount of painful contraction of the muscles affected by relaxin.

### Claim 2 (depends on 1)

The method of claim 1 wherein the step of administration comprises oral administration.

### Claim 3 (depends on 1)

The method of claim 1 wherein the step of administration comprises administration by injection.

### Claim 4 (depends on 3)

The method of claim 3 wherein the injection is delivered in a regional muscle area exhibiting pain.

### Claim 5 (depends on 4)

The method of claim 4 wherein the injection is delivered in a select muscle of the regional muscle area exhibiting pain.

### Claim 6 (depends on 1)

The method of claim 1 wherein the step of administration comprises a combination of at least two methods selected from the group consisting of topical, injection and oral methods.

### Claim 7 (depends on 1)

The method of claim 1 wherein the step of administration comprises administrations transdermally through skin patches.

### Claim 8 (depends on 1)

The method of claim 1 wherein the step of administration comprises administration transdermally.

### Claim 9 (depends on 1)

The method of claim 1 wherein the method of administering the relaxin hormone is by subcutaneous injection of a liquid pharmaceutical formulation comprising a therapeutically effective amount of human relaxin.

### Claim 10

A method of treating myofascial pain syndrome by concomitantly administering to a patient exhibiting painful contraction of muscles from involuntary muscle dysfunction of a therapeutically effective amount of:
(1) relaxin hormone; and
(2) at least one of estrogen and progesterone, thereby decreasing the amount of painful contraction of muscles affected by relaxin.

### Claim 11

A method of treating myofascial pain syndrome in a patient exhibiting painful contraction of muscles from myofascial pain syndrome, the method consisting of administering a therapeutically effective amount of relaxin, selected from the group consisting of natural human relaxin, synthetic human relaxin, and animal relaxin, thereby decreasing the amount of contraction of the muscles affected by relaxin.