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US 5,863,551 AGranted
Implantable polymer hydrogel for therapeutic uses
AssigneeOrganogel Canada LTEE
InventorStephane Woerly
Life of this patent
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Abstract
The hydrogel is a copolymer of an N-substituted methacrylamide or acrylamide, a cross-linking agent and a complex sugar or derivative, a tissue adhesion peptide or a polymer conjugate with antibodies, the polymer being heterogeneous, elastically deformable and having an equilibrium water content of at least about 80%. It can be used for tissue regeneration and for organ repair, for example, in the developing and adult nervous system.
Claims14
A polymer hydrogel for therapeutic use, comprising:
- a copolymer of (a) and N-substituted methacrylamide or acrylamide, (b) a cross-linking agent and (c) at least one type of copolymerizable, biologically active molecule, which is a complex sugar, a sugar derivative or a tissue adhesive peptide, said polymer hydrogel being heterogeneous, elastically deformable and having an equilibrium water content of at least about 80%, a fractional porosity of at least 80-90%, a mean pore diameter of about 15-35 .mu.m and a porous volume of pores measuring at least 10 .mu.m equal to substantially 100% of the total fractional porosity of the hydrogel.
A method for preparing a heterogeneous, elastically deformable hydrogel for therapeutic use, which comprises:
- (a) dissolving a cross-linking agent in a solvent with a free radical polymerization initiator selected from the group consisting of azobisisobutyronitrile, a peroxide, ascorbic acid, a peroxysulfate or a substituted azo compound, said initiator being present in an amount ranging from 0.01-2% by weight with respect to the polymer hydrogel which is formed, to form a solution;
- (b) adding an N-substituted methacrylamide or acrylamide to the solution obtained in (a) to form a mixture,
- (c) adding a solution of a copolymerizable, biologically active molecule, which is a complex sugar, a sugar derivative or a tissue adhesive peptide, to said solution;
- and
- (d) polymerizing the components (a) to (c), thereby obtaining a polymer hydrogel which is heterogeneous, elastically deformable and has an equilibrium water content of at least about 80%, a fractional porosity of at least 80-90%, a mean pore diameter of about 15-25 .mu.m and a porous volume of pores measuring at least 10 .mu.m equal to substantially 100% of the total fractional porosity of the hydrogel.
2 more elements
Dependencies are inferred from the claim text.