Reductive alkylation process to prepare tertiary aminoaryl compounds
AssigneeEastman Kodak Company
InventorVictor L. Mylroie
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Abstract
Tertiary aminoaryl compounds, such as N,N'dialkylaminoaryl compounds, are prepared using successive reductive steps without isolation therebetween, at high temperature and pressure. A nitroaryl compound is reduced using a ketone as both solvent and reactant in a reductive environment, and the resulting intermediate is further reacted with an aldehyde in the same reaction mixture without isolation to provide the second substituent on the amino group.
Claims20
A method for preparing a tertiary aminoaryl compound comprising reacting a secondary aminoaryl at high temperature and pressure with an aldehyde in a reductive environment and in the presence of a ketone and a hydrogenation catalyst for at least 2 hours.
A method for preparing a tertiary aminoaryl compound comprising:
- A) reducing a nitroaryl in the presence of a ketone solvent in a reductive environment to provide a secondary aminoaryl compound, and
- B) without isolation from the reaction mixture used in step A, and upon the addition of an aldehyde, reacting said secondary aminoaryl compound with said aldehyde in the presence of said ketone and in a reductive environment at high temperature and pressure for at least 2 hours to provide said tertiary aminoaryl compound.
The method of claim 19 wherein R.sub.4 is an N-blocking group, and both of R.sub.2 and R.sub.3 is alkyl group.
Dependencies are inferred from the claim text.