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US 5,861,525 AGranted
Method for preparing cyanophosphonate derivatives from phosphate esters and cyanide
AssigneeMonsanto Company
InventorsPatrick J. Lennon, Sergey G. Vulfson
Life of this patent
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Abstract
A process for preparing cyanophosphonate derivatives involves contacting a phosphate ester and cyanide in a reaction mixture under conditions sufficient to produce a cyanophosphonate derivative. That cyanophosphonate derivative product can subsequently be hydrogenated to produce an aminomethylphosphonate derivative.
Claims55
A process for preparing a cyanophosphonate derivative comprising:
- contacting a phosphate ester of the formula:
- ##STR4## wherein R, R.sup.1 and R.sup.2 are the same or different and are defined as an aryl group, an arylalkyl group, a vinyl group or a straight or branched alkyl group having from 1 to 20 carbon atoms, and a cyanide in a reaction mixture under sufficient conditions to produce a cyanophosphonate derivative.
A process for preparing an aminomethylphosphonate derivative comprising:
- contacting a phosphate ester of the formula:
- ##STR5## wherein R, R.sup.1 and R.sup.2 are the same or different and are defined as an aryl group, an arylalkyl group, a vinyl group or a straight or branched alkyl group having from 1 to 20 carbon atoms, and a cyanide in a reaction mixture under sufficient conditions to produce a cyanophosphonate derivative;
- and
- hydrogenating the cyanophosphonate derivative in the presence of a suitable catalyst under sufficient conditions to produce an aminomethylphosphonate derivative.
1 more element
Dependencies are inferred from the claim text.