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US 5,861,511 AGranted
Process for preparation of 3 piperazinylbenzisothiazoles
AssigneeSumitomo Seika Chemicals Co., Ltd.
InventorsHiroshi Goda, Junichi Sakamoto, Shigeki Sakaue, Sakae Kajihara, Miki Todo
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Abstract
There is disclosed a process for preparing 3-piperazinylbenzisothiazoles comprising reacting the specified 3-halo-1,2-benzisothiazole or 2-cyanobenzenesulfenyl halide in the presence of an alkylene glycol derivative. The process is industrially effective, easy and economical and can provide useful intermediates for production of pharmaceutical preparations.
Claims4
A process for preparing 3-piperazinylbenzisothiazoles represented by the general formula (IV):
- ##STR8## where R.sub.1 represents hydrogen, or alkyl group having 1 to 6 carbon atoms, which comprises:
- reacting 2-cyanobenzenesulfenyl halide represented by the general formula (V):
- ##STR9## wherein X represents Cl or Br, with a piperazine compound represented by the general formula (II):
- ##STR10## wherein R.sub.1 is as defined for (IV) , in the presence of an alkylene glycol derivative represented by the general formula (III):
- ##STR11## wherein R.sub.2 and R.sub.3 each represent hydrogen, or linear or branched alkyl group each having 1 to 4 carbon atoms, and n represents 2 to 4.
2 more elements
Dependencies are inferred from the claim text.