Purification of a cephalosporin salt
AssigneeBiochemie Gesellschaft m.b.H.
InventorsJohannes Ludescher, Rainer Pucher, Siegfried Wolf
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Abstract
A p-toluenesulphonic acid salt of 7-2-(2-aminothiazol-4-yl)-2-(Z)-hydroximino-acetamido!-3-N,N-dimethylcarb amoyloxymethyl-3-cephem-4-carboxylic acid (isopropoxycarbonyloxy)ethylester, e.g. of formula ##STR1## its use in the production of other salts and a pharmaceutical composition containing it.
Claims5
A process for the production of a salt of 7-2-(2-aminothiazol4-yl)-2-(Z)-hydroximinoacetamido!-3-N,N-dimethylcarbam oyloxymethyl-3-cephem-4-carboxylic acid (isopropoxycarbonyloxy)ethylester which comprises converting a p-toluene-sulphonic acid salt of 7-2-(2-aminothiazol4-yl)-2-(Z)-hydroximinoacetamido!-3-N,N-dimethylcarbam oyloxymethyl-3-cephem-carboxylic acid (isopropoxycarbonyloxy)ethylester into a different salt with of 7-2-(2-aminothiazol-4-yl)-2-(Z)-hydroximino-acetamido!-3-N,N-dimethylcarb amoyloxymethyl-3-cephem-carboxylic acid (isopropoxycarbonyloxy)ethylester.
A pharmaceutical composition comprising a carrier and, as active ingredient, a p-toluene-sulfonic acid salt of 7-2-(2-aminothiazol-4-yl)-2-(Z)-hydroximino-acetamido!-3-N,N-dimethylcarb amoyloxymethyl-3-cephem-carboxylic acid (isopropoxycarbonyloxy)ethylester.
Dependencies are inferred from the claim text.