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US 5,861,505 AGranted
Synthetic analog of sialic Lewis antigen from bacterial capsular polysaccharide
AssigneeCalifornia Institute of Technology
InventorRoger G. Kern
Life of this patent
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Abstract
An analog of sialic Lewis antigen prepared from native capsular polysaccharide of Klebsiella 63 bacteria.
Claims2
An analog of sialic Lewis antigen of the structure:
- .alpha.NeuAc-.beta.(2-3)-Gal-.alpha.(1-3)-GalA-.alpha.(1-3)-Fuc.
A method for producing synthetic sialic Lewis antigen analogue comprising the steps of:
- a) isolating capsular polysaccharide of Klebsiella K 63;
- b) exhaustively digesting the isolated capsular polysaccharide of Klebsiella K 63 with K63 phage lysate;
- c) adding sialic acid to the non-reducing terminus of the galactose monomer of the exhaustively digested capsular polysaccharide of step b) above;
- and
- d) purifying the resulting tetramer.
2 more elements
Dependencies are inferred from the claim text.