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AssigneeThomas Jefferson University
InventorsEmad S. Alnemri, Teresa Fernandes-Alnemri, Gerald Litwack
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A substantially pure protein, immunophilin FKBP46, is disclosed. An isolated nucleic acid molecule that comprises a nucleic acid sequence that encodes immunophillin FKBP46, is disclosed. An isolated nucleic acid molecule consisting of a nucleic acid sequence that encodes immunophillin FKBP46, or a fragment thereof having at least 10 nucleotides is disclosed. Recombinant expression vector comprising a nucleic acid sequence that encodes immunophillin FKBP46 and host cells comprising the recombinant expression vector are disclosed. Oligonucleotide molecule comprising a nucleotide sequence complimentary to a nucleic acid sequence that encodes immunophillin FKBP46 of at least 5 nucleotides are disclosed. Antibodies that binds to an epitope on FKBP46 are disclosed. Methods of identifying immunosuppressive drugs comprising the steps of contacting FKBP46 or a homologous protein derived from yeast with a test compound and determining whether the protein binds to the test compound are disclosed.
An isolated nucleic acid molecule that comprises a nucleic acid sequence that encodes the protein having the amino acid sequence of SEQ ID NO:2.
An isolated nucleic acid molecule consisting of SEQ ID NO:1 or a fragment thereof having at least 10 contiguous nucleotides of a unique nucleotide sequence of SEQ ID NO:1.
An oligonucleotide molecule comprising a nucleotide sequence complimentary to a nucleotide sequence of at least 10 contiguous nucleotides of a unique nucleotide sequence of SEQ ID NO:1.
An isolated nucleic acid molecule consisting of SEQ ID NO:1 or a fragment thereof having at least 24 contiguous nucleotides of SEQ ID NO:1.
An oligonucleotide molecule comprising a nucleotide sequence of at least 24 contiguous nucleotides of SEQ ID NO:1.
An isolated nucleic acid molecule consisting of SEQ ID NO:1 or a fragment thereof having at least 10 contiguous nucleotides of a nucleotide sequence selected from the group consisting of:
An oligonucleotide molecule comprising a nucleotide sequence complimentary to a nucleotide sequence of at least at least 10 contiguous nucleotides of a nucleotide sequence selected from the group consisting of:
Dependencies are inferred from the claim text.