Colon specific gene and protein
AssigneeHuman Genome Sciences, Inc.
InventorsDaniel R. Soppet, Yi Li, Patrick J. Dillon
Life of this patent
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Abstract
Human colon specific gene polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polynucleotides or polypeptides as a diagnostic marker for colon cancer and as an agent to determine if colon cancer has metastasized. Also disclosed are antibodies specific to the colon specific gene polypeptides which may be used to target cancer cells and be used as part of a colon cancer vaccine. Methods of screening for agonists and antagonists for the polypeptide and therapeutic uses of the antagonists are also disclosed.
Claims25
An isolated polynucleotide comprising a member selected from the group consisting of:
- (a) a polynucleotide sequence encoding a polypeptide comprising amino acids 2 to 158 of SEQ ID NO:2;
- and
- (b) the full complement of (a).
An isolated polynucleotide comprising a member selected from the group consisting of:
- (a) a polynucleotide sequence encoding the same mature polypeptide encoded by the human cDNA in ATCC Deposit No. 97129;
- (b) the full complement of (a).
An isolated polynucleotide comprising a polynucleotide sequence that will hybridize under stringent conditions to a member selected from the group consisting of:
- (a) a polynucleotide sequence encoding amino acids 2 to 158 of SEQ ID NO:2;
- and
- (b) the full complement of (a).
An isolated polynucleotide comprising a polynucleotide sequence that will hybridize under stringent conditions with a member selected from the group consisting of:
- (a) a polynucleotide sequence encoding the mature polypeptide encoded by the human cDNA in ATCC Deposit No. 97129, and
- (b) the full complement of (a).
Dependencies are inferred from the claim text.