Morphogen cell surface receptor
AssigneeCreative BioMolecules, Inc.
InventorsDonald F. Jin, Hermann Oppermann, Thangavel Kuberasampath, John E. Smart
Life of this patent
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Abstract
Disclosed are (1) nucleic acid sequences, amino acid sequences, homologies, structural features and various other data characterizing a morphogen cell surface receptor; (2) methods for producing receptor proteins, including fragments thereof, using recombinant DNA technology; (3) methods for identifying novel morphogen receptors and their encoding DNAs; (4) methods for identifying compounds capable of modulating endogenous morphogen receptor levels; and (5) methods for identifying morphogen receptor binding analogs useful in the design of morphogen agonists and antagonists for therapeutic, diagnostic and experimental uses.
Claims7
A purified polypeptide encoded by a DNA shown in SEQ ID NO:
- 1, or a allelic or species variant thereof, wherein said polypeptide has binding specificity for OP-1 or BMP2 while not significantly binding to TGF-.beta. or activin and wherein the polypeptide is about 500 amino acids and has a molecular weight of about 58-90 kDa.
A purified polypeptide comprising amino acids 25-247 of SEQ ID NO:
- 2 or a allelic or species variant thereof, wherein said polypeptide has binding specificity for a morphogen selected from the group consisting of OP-1 or BMP2 while not significantly binding to TGF-.beta. or activin and wherein the polypeptide is about 500 amino acids and has a molecular weight of about 58-90 kDa.
A purified polypeptide comprising amino acids 25-516 of SEQ ID NO:
- 2 or a allelic or species variant thereof, wherein said polypeptide has binding specificity for a morphogen selected from the group consisting of OP-1 or BMP2 while not significantly binding to TGF-.beta. or activin and wherein the polypeptide is about 500 amino acids and has a molecular weight of about 58-90 kDa.
A polypeptide encoded by a nucleic acid that can be isolated by amplification with a first and a second nucleic acid primer, wherein said primers have sequences selected from the group consisting of SEQ ID NO:
- 4, SEQ ID NO:
- 5, SEQ ID NO:
- 6, or SEQ ID NO:
- 7, and wherein said polypeptide has binding specificity for a morphogen selected from the group consisting of OP-1 or BMP2 while not significantly binding to TGF-.beta. or activin and wherein the polypeptide is about 500 amino acids and has a molecular weight of about 58-90 kDa.
Dependencies are inferred from the claim text.