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US 5,861,477 AGranted
Cyclic peptide catalysts modeled on enzyme active sites
OwnerM. Zouhair Atassiinventor
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OwnerM. Zouhair Atassiinventor
Estimating the term…
PEPZYMES.TM., chemically synthesized cyclic peptides, modeled on the active sites of naturally-occurring enzymes represented by chymotrypsin, trypsin, lysozyme, ribonuclease, urokinase, tissue plasminogen activator and their analogs are disclosed. The conformational constraints imposed on the peptide residues cause the amino acids of the peptide to assume a three-dimensional spatial relationship relative to the substrate that is essentially equivalent to that of the corresponding active site amino acids of the natural enzyme in its catalytically active state. The new cyclic peptides catalyze the same reaction as the native enzyme being modeled, but have amino acid sequences that are substantially shorter than the naturally-occurring enzymes, and do not occur in the same linear relationship in the naturally-occurring enzymes. Methods of producing PEPZYMES.TM. are described.
A peptide modeled on an active site of a naturally occurring enzyme and having the structure:
A peptide modeled on an active site of a naturally occurring enzyme and having the structure:
A peptide modeled on an active site of a naturally occurring enzyme and having the structure:
A peptide modeled on an active site of a naturally occurring enzyme and having the structure:
A peptide modeled on an active site of a naturally occurring enzyme and having the structure:
A peptide modeled on an active site of a naturally occurring enzyme and having the structure:
Dependencies are inferred from the claim text.