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US 5,861,313 AGranted
Method of isolating bile duct progenitor cells
AssigneeOntogeny, Inc.
InventorsKevin K. Pang, Monica W. Homa
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Abstract
The present invention relates to a substantially pure population of viable bile duct progenitor cells, and methods for isolating such cells. The present invention further concerns certain therapeutic uses for such progenitor cells, and their progeny.
Claims16
A method for isolating progenitor cells from a bile duct comprising
- culturing a bile duct explant comprising both an epithelial layer and a stromal layer, which explant retains in culture the original epithelial-mesenchymal microarchitecture of a mammalian bile duct, wherein said explant is maintainable in culture for at least twenty-four hours, and wherein said explant includes at least on progenitor cell which has the ability to proliferate;
- contacting said explant with an agent which causes proliferation of progenitor cells in said explant;
- and
- isolating from said explant progenitor cells that proliferate in response to said agent.
1 more element
Dependencies are inferred from the claim text.