Loading patent…
AssigneeThe Picower Institute for Medical Research
InventorsYong Ming Li, Helen Vlassara, Anthony Cerami
Estimating the term…
The present invention is directed to methods for partitioning advanced glycosylation endproducts out of a biological sample using the unexpected discovery that certain antibacterial proteins, in particular lysozyme and particular fragments thereof, bind to advanced glycosylation endproducts (AGEs) with high affinity, and that this binding activity is substantially noncompetitive with binding of bacterial carbohydrates to the antibacterial proteins. Accordingly, the invention relates to therapeutic methods for treating diseases and disorders associated with increased levels of AGEs, by using compositions having associated therewith a molecule having a hydrophilic loop domain, which domain is associated with AGE-binding activity, and compositions comprising such a domain to remove AGEs from biological material. The invention further relates to compositions and devices for partitioning AGEs away from a sample.
A method for partitioning advanced glycosylation endproducts (AGEs) out of a biological sample comprising contacting the sample with a molecule effective to partition AGEs in a biological sample under conditions where specific binding of the molecule and AGEs can occur, said molecule having a structure corresponding to R.sub.1 Cys.sub.1 Xaa.sub.n Cys.sub.2 R.sub.2 (SEQ ID NOS:
Dependencies are inferred from the claim text.