Temperature sensitive gel for sustained delivery of protein drugs
AssigneeUniversity Technology Corporation
InventorsLewis P. Stratton, John F. Carpenter, Mark C. Manning
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Abstract
Pharmaceutical compositions for the delivery of pharmacologically active proteins are provided by the present invention. The compositions of the present invention comprise a polymeric matrix having thermal gelation properties in which is incorporated a discrete suspension of at least one biologically active macromolecular polypeptide which retains greater than 90 percent of its biological activity. Furthermore, the concentration of the macromolecular polypeptide is greater than 0.5 percent by weight of the composition.
Claims32
A pharmaceutical composition for the controlled and sustained administration of biologically active macromolecular polypeptides comprising a polymeric matrix having thermal gelation properties in which aqueous soluble particles of at least one biologically active macromolecular polypeptide at a concentration sufficient to form a suspension when incorporated into said polymeric matrix are incorporated into said polymeric matrix.
A pharmaceutical composition for the controlled and sustained administration of a biologically active macromolecular polypeptide comprising a polymeric matrix in which a suspension of aqueous soluble macromolecular polypeptide particles is incorporated.
Dependencies are inferred from the claim text.