Skin equivalent comprising langerhans' cells
AssigneeSociete L'Oreal S.A.
InventorsRainer Schmidt, Marcelle Regnier, Daniel Schmitt, Marie-Jeanne Staquet
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Abstract
The present invention relates to a reconstructed skin model, characterized in that it comprises an epidermis equivalent on a support, the said epidermis equivalent comprising at least keratinocytes and at least induced or noninduced precursors of Langerhans' cells, as well as the process for preparing the said skin equivalent. The invention also relates to an epidermis equivalent, characterized in that it comprises at least keratinocytes and at least induced or noninduced precursors of Langerhans' cells and to the process for preparing it.
Claims36
Skin equivalent which comprises an epidermis equivalent on a support, said epidermis equivalent comprising keratinocytes and induced or noninduced precursors of Langerhans' cells wherein the ratio of the number of keratinocytes to the induced or noninduced precursors of Langerhans' cells ranges from 95/5 to 25/75 based on the percentage of the total number of cells in the epidermis equivalent.
Process for preparing a skin equivalent, which comprises co-cultivating keratinocytes and at least induced or noninduced precursors of Langerhans' cells on a support.
Epidermis equivalent, which comprises keratinocytes and induced or noninduced precursors of the Langerhans' cells.
Dependencies are inferred from the claim text.