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US 5,859,432 AGranted
Method and apparatus for direct coupling of liquid chromatograph and mass spectrometer liquid, chromatography--mass spectrometry, and liquid chromatograph--mass spectrometer
AssigneeHitachi, Ltd.
InventorsYoshiaki Kato, Tadao Mimura
Life of this patent
Estimating the term…
Abstract
A nebulized jet from a nebulizer is subjected to mechanical agitation and stirring to render the mists uniform and fine, then the droplets of the mists thus rendered uniform and fine are ionized. By accelerative collision of the resulting ions in a medium pressure chamber it is made possible to effect desolvation efficiently. Consequently, chemical noises caused by cluster ions can be greatly diminished and it is possible to attain high sensitive measurement of a sample in atmospheric pressure ionizations LC/MS.
Claims35
An apparatus for coupling a liquid chromatograph and a mass spectrometer comprising:
- an interface portion between the liquid chromatograph and the mass spectrometer,
- said interface portion including:
- a nebulizer nebulizing a sample solution under atmospheric pressure or a pressure equivalent thereto;
- a heater heating mists resulting from said nebulizer by conducting the mists into a heated space surrounded with a heated material, wherein said heated space includes a passage, said passage having a bent formation such that a flow direction of the bent passage differs from a flow direction of the nebulized mists thereby stirring the mist;
- an ionizer ionizing the sample solution included in the heated mists by ion-molecule reaction under atmospheric pressure or a pressure equivalent thereto;
- and
- an introducer introducing the resulting ions into the mass spectrometer.
4 more elements
A method for coupling liquid chromatograph and a mass spectrometer comprising steps of:
- coupling the liquid chromatograph and the mass spectrometer using an interface portion;
- said interface performing steps of:
- nebulizing a sample solution under atmospheric pressure or a pressure equivalent thereto;
- heating mists resulting from said nebulizer by conducting the mists into a heated space surrounded with a heated material, wherein said heated space includes a passage, said passage having a bent formation such that a flow direction of the bent passage differs from a flow direction of the nebulized mists thereby stirring the mists;
- ionizing the sample solution included in the heated mists by ion-molecule reaction under atmospheric pressure or a pressure equivalent thereto;
- and
- introducing the resulting ions into the mass spectrometer.
4 more elements
A liquid chromatograph mass spectrometer comprising:
- a liquid chromatograph;
- a nebulizer nebulizing effluent from said liquid chromatograph;
- a heater including a passage heating mists resulting from said nebulizer by heat conduction wherein said passage has a bent formation such that a flow direction of the bent passage differs from a flow direction of the nebulized mist thereby stirring the mist;
- an ionizer dissolving and ionizing the heated mists;
- and
- a mass spectrometer for mass spectrometric analysis of the resulting ions.
3 more elements
A liquid chromatograph mass spectrometer comprising:
- a liquid chromatograph;
- a nebulizer nebulizing effluent from said liquid chromatograph;
- a heater heating mists resulting from said nebulizer;
- an ionizer desolving and ionizing the heated mists;
- a mass spectrometer providing mass spectrometric analysis of the resulting ions;
- and
- a stirrer stirring almost all of the mists during said heating of the mists.
4 more elements
A liquid chromatograph mass spectrometer comprising:
- a liquid chromatograph;
- a nebulizer nebulizing effluent from said liquid chromatograph;
- a heater heating the nebulized effluent wherein said heater includes a passage, said passage having a bent formation such that a flow direction of the bent passage differs from a flow direction of the nebulized effluent;
- an ionizer ionizing mists resulting from said nebulizer;
- a mass spectrometer providing mass spectrometric analysis of the resulting ions;
- and
- a selector selecting a portion of the mists.
4 more elements
A liquid chromatograph mass spectrometer comprising:
- a liquid chromatograph;
- an ionizer nebulizing and ionizing effluent from said liquid chromatograph under atmospheric pressure;
- a desolvator desolvating mists ionized by said ionizer;
- a mass spectrometer providing mass spectrometric analysis of the desolvated ions in high vacuum;
- and
- a stirrer stirring almost all of the mists.
3 more elements
A liquid chromatograph mass spectrometer comprising:
- a liquid chromatograph;
- a nebulizer nebulizing effluent from said liquid chromatograph under atmospheric pressure;
- a corona discharge ionizer conducting mists resulting from said nebulizer to an electrode and ionizing the mists by corona discharge;
- a desolvator desolvating mists ionized from said ionizer;
- a mass spectrometer providing mass spectrometric analysis of the desolvated ions in high vacuum;
- and
- a stirrer stirring almost all of the mists.
4 more elements
A method for coupling a chromatograph and a mass spectrometer comprising:
- coupling the liquid chromatograph and the mass spectrometer with an interface portion,
- said interface portion having:
- a nebulizer nebulizing a sample solution under atmospheric pressure or a pressure equivalent thereto;
- a heater heating mists resulting from said nebulizer by conducting the mists into a space surrounded with a heated material, said heated space being not formed rectilinearly, and wherein said heated space includes a passage, said passage having a bent formation such that a flow direction of the bent passage differs from a flow direction of the nebulized mists;
- an ionizer ionizing the sample solution included in the heated mists by ion-molecule reaction under atmospheric pressure or a pressure equivalent thereto, and
- an introducer introducing the resulting ions into the mass spectrometer.
3 more elements
An apparatus for coupling a liquid chromatograph and a mass spectrometer comprising:
- an interface portion coupling the liquid chromatograph and the mass spectrometer;
- said interface portion including:
- a nebulizer nebulizing a sample solution and producing mists;
- a heater heating the nebulized effluent wherein said heater includes a passage, said passage having a bent formation such that a flow direction of the bent passage differs from a flow direction of the nebulized effluent;
- a reducing device reducing diameters of almost all of the mists;
- and
- an ionizer ionizing the sample solution included in the mists.
4 more elements
An apparatus for coupling a liquid chromatograph and a mass spectrometer comprising:
- an interface portion coupling the liquid chromatograph and the mass spectrometer;
- said interface portion including:
- a nebulizer nebulizing a sample solution and producing mists;
- a heater heating the nebulized effluent wherein said heater includes a passage, said passage having a bent formation such that a flow direction of the bent passage differs from a direction of the nebulized effluent;
- an averaging device averaging diameters of almost all of the mists;
- and
- an ionizer ionizing the sample solution included in the mists.
4 more elements
An apparatus for coupling a liquid chromatograph and a mass spectrometer comprising:
- an interface portion coupling the high-speed liquid chromatograph and the mass spectrometer;
- said interface portion including:
- a nebulizer nebulizing a sample solution and producing mists;
- a stirring device stirring almost all of the mists;
- and
- an ionizer ionizing the sample solution included in the mists.
3 more elements
A method for coupling a liquid chromatograph and a mass spectrometer comprising:
- (a) nebulizing an effluent at atmospheric pressure or equivalent thereto;
- (b) heating the effluent in a passage wherein said passage has a bent formation such that a flow direction of the bent passage differs from a flow direction of the nebulized effluent thereby change the effluent at atmospheric pressure or equivalent thereto;
- (c) ionizing the effluent at atmospheric pressure or equivalent thereto;
- (d) receiving the effluent at a pressure lower than atmospheric pressure;
- and
- (e) analyzing the effluent at a pressure lower than the pressure in said receiving step (d).
3 more elements
An apparatus for coupling a liquid chromatograph and a mass spectrometer comprising:
- an interface portion between the liquid chromatograph and the mass spectrometer,
- said interface portion including:
- a nebulizer nebulizing a sample solution under atmospheric pressure or a pressure equivalent thereto;
- a heater heating mists resulting from said nebulizer by conducting the mists into a heated space surrounded with a heated material wherein said heated space includes an obstructing object used to create a turbulent flow in a downstream direction of the heated mist thereby stirring the mist;
- an ionizer ionizing the sample solution included in the heated mists by ion-molecule reaction under atmospheric pressure or a pressure equivalent thereto, and
- an introducer introducing the resulting ions into the mass spectrometer.
3 more elements
A method for coupling a liquid chromatograph and a mass spectrometer comprising steps of:
- coupling the liquid chromatograph and the mass spectrometer using an interface portion;
- said interface performing steps of:
- nebulizing a sample solution under atmospheric pressure or a pressure equivalent thereto;
- heating mists resulting from said nebulizer by conducting the mists into a heated space surrounded with a heated material wherein said heated space includes an obstructing object used to create a turbulent flow in a downstream direction of the heated mist, thereby
- stirring the mists;
- ionizing the sample solution included in the heated mists by ion-molecule reaction under atmospheric pressure or a pressure equivalent thereto;
- and
- introducing the resulting ions into the mass spectrometer.
5 more elements
A liquid chromatograph mass spectrometer comprising:
- a liquid chromatograph;
- a nebulizer nebulizing effluent from said liquid chromatograph;
- a heater heating mists resulting from said nebulizer by heat conduction wherein said heater includes an obstructing object used to create a turbulent flow in a downstream direction of the heated mist thereby stirring the mist;
- an ionizer dissolving and ionizing the heated mists;
- and
- a mass spectrometer for mass spectrometric analysis of the resulting ions.
3 more elements
A liquid chromatograph mass spectrometer comprising:
- a liquid chromatograph;
- a nebulizer nebulizing effluent from said liquid chromatograph;
- a heater including an obstructing object used to create a turbulent flow in a downstream direction of the heated effluent;
- an ionizer dissolving and ionizing mists resulting from said nebulizer;
- a mass spectrometer providing mass spectrometric analysis of the resulting ions;
- and
- a selector selecting a portion of the mists.
4 more elements
An apparatus for coupling a liquid chromatograph and a mass spectrometer comprising:
- an interface portion coupling the liquid chromatograph and the mass spectrometer,
- said interface portion having:
- a nebulizer nebulizing a sample solution under atmospheric pressure or a pressure equivalent thereto;
- a heater heating mists resulting from said nebulizer by conducting the mists into a space surrounded with a heated material wherein said heated space includes an obstructing object used to create a turbulent flow in a downstream direction of the heated mist;
- an ionizer ionizing the sample solution included in the heated mists by ion-molecule reaction under atmospheric pressure or a pressure equivalent thereto;
- an introducer introducing the resulting ions into the mass spectrometer;
- and
- a member disposed within said heated space through which the mists pass, said member capable of once dividing the flow of the mists and again stirring almost all of the divided mist flows.
5 more elements
An apparatus for coupling a liquid chromatograph and a mass spectrometer comprising:
- an interface portion coupling the liquid chromatograph and the mass spectrometer;
- said interface portion including:
- a nebulizer nebulizing a sample solution and producing mists;
- a heater heating the mist wherein the heater includes an obstructing object used to create a turbulent flow in a downstream direction of the heated mist;
- a reducing device reducing diameters of almost all of the mists;
- and
- an ionizer ionizing the sample solution included in the mists.
4 more elements
An apparatus for coupling a high-speed liquid chromatograph and a mass spectrometer comprising:
- an interface portion coupling the liquid chromatograph and the mass spectrometer;
- said interface portion including:
- a nebulizer nebulizing a sample solution and producing mists;
- a heater heating the mist wherein the heater includes an obstructing object used to create a turbulent flow in a downstream direction of the heated mist;
- an averaging device averaging diameters of almost all of the mists;
- and
- an ionizer ionizing the mists.
4 more elements
Dependencies are inferred from the claim text.