Process for the hydrogenation of imines
AssigneeNovartis AG
InventorsHans-Peter Jalett, Bernd Siebenhaar
Life of this patent
Estimating the term…
Abstract
A process for the hydrogenation of imines with hydrogen under elevated pressure in the presence of iridium catalysts containing diphosphine ligands, with or without an inert solvent, the reaction mixture containing a soluble ammonium chloride, bromide or iodide or a soluble metal chloride, bromide, or iodide, wherein the reaction mixture additionally contains at least one solid acid with the exception of ion exchangers. Improved optical yields and high chemical conversion rates are achieved while the catalyst is easily separable.
Claims57
A process for the hydrogenation of an imine with hydrogen under elevated pressure in the presence of an iridium catalyst containing diphosphine ligands, with or without an inert solvent, the reaction mixture containing a soluble ammonium chloride, bromide or iodide or a soluble metal chloride, bromide or iodide, wherein the reaction mixture additionally contains at least one solid acid with the exception of ion exchangers.
A process according to claim 29, wherein the molar ratio of imine to iridium catalyst is from 1 000 000 to 1000.
Dependencies are inferred from the claim text.