Process for the preparation of 2-halogeno-4,5-difluorobenzoyl fluorides
AssigneeBayer Aktiengesellschaft
InventorsStefan Antons, Albrecht Marhold, Bernhard Beitzke
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Abstract
2-Halogeno-4,5-difluoro-benzoyl fluorides are obtained in high yields by reacting 2,4-dichloro-5-fluoro-benzoyl halides with potassium fluoride in an aprotic solvent. The 2-halogeno-4,5-difluoro-benzoyl fluorides prepared in this way are particularly suitable as intermediates for the preparation of antibacterial active substances.
Claims6
A process for producing a mixture containing 2,4,5-trifluoro benzoyl fluoride and 2-chloro-4,5-difluoro-benzoyl fluoride and less than 1% by weight of 4-chloro-2,5-difluoro-benzoyl fluoride which comprises reacting 2,4-dichloro-5-luoro-benzoyl chloride with 3.1 to 4.5 moles of potassium fluoride per mole of 2,4-dichloro-5-fluoro-benzoyl chloride in an aprotic solvent and thereafter distilling the reaction mixture.
Dependencies are inferred from the claim text.