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US 5,859,271 AGranted
Cytoprotective compounds
AssigneeVirginia Commonwealth University
InventorsRichard C. Franson, Raphael M. Ottenbrite
Life of this patent
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Abstract
The present invention provides compositions and methods for protecting cells from injury due to intrinsic membrane lysis, oxidation and/or invasion by destructive agents. Even more particularly, the present invention provides compositions and methods for treating or prophylactically inhibiting phospholipase mediated injury, injury due to oxidation, and inflammation. In a very specific sense, this invention provides compositions and methods of making these compositions that are inhibitors of phospholipase.
Claims12
A composition comprising:
- ##STR20## wherein A comprises H, OH, NH.sub.2, or an acid or salt thereof;
- B is selected from the group consisting of N, NR, P, P.dbd.O, CH and CR, wherein R is an alkyl chain of 1 to 6 carbons and the chain may be functionalized or non-functionalized;
- C.sub.1, C.sub.2 and C.sub.3 are connecting groups which may be different and are selected from the group consisting of --(CH.sub.2).sub.n -- and (CH.sub.2 CH.sub.2 --O)y wherein n is an integer from 1 to 24, --(CH.sub.2).sub.n -- may be functionalized or non-functionalized, and y is an integer from 1 to 12;
- and
- D.sub.1 and D.sub.2 are fatty acid chains which may be different and are selected from the group consisting of fatty acid esters of the form CH.sub.3 (CH.sub.2).sub.n COO, and fatty acid amides of the form CH.sub.3 (CH.sub.2).sub.n CONH, wherein n is an integer from 1 to 32, at least one of the fatty chains is cis-unsaturated at one or more positions, and the fatty chains may be of different lengths and may be unsaturated at different locations.
2 more elements
Dependencies are inferred from the claim text.