Hypolipidemic benzothiazepine compounds
AssigneeGlaxo Wellcome Inc.
InventorLawrence Edward Brieaddy
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Abstract
The present invention is concerned with processes for preparing hypolipidaemic benzothiazepine compounds of formula (I) ##STR1## wherein l is an integer of from 0 to 4; m is an integer of from 0 to 5; n is an integer of from 0 to 2; R and R' are atoms or groups independently selected from halogen, nitro, phenylalkoxy, C.sub.1-4 alkoxy, C.sub.1-6 alkyl and --O(CH.sub.2).sub.p SO.sub.3 R" wherein p is an integer of from 1 to 4 and R" is hydrogen or C.sub.1-6 alkyl, wherein said phenylalkoxy, alkoxy and alkyl groups are optionally substituted by one or more halogen atoms; R.sup.4 is C.sub.1-6 straight alkyl group; and R.sup.5 is a C.sub.2-6 straight alkyl group; and their salts, solvates and physiologically functional derivatives; and intermediates useful in said processes.
Claims2
A method for the preparation of a compound of formula (I) ##STR19## wherein l is an integer of from 0 to 4;
- m is an integer of from 0 to 5;
- n is an integer of from 0 to 2;
- R and R' are atoms or groups independently selected from halogen, nitro, phenylalkoxy, C.sub.1-4 alkoxy, C.sub.1-6 alkyl and --O(CH.sub.2).sub.p SO.sub.3 R" wherein p is an integer of from 1 to 4 and R" is hydrogen or C.sub.1-6 alkyl, wherein said phenylalkoxy, alkoxy and alkyl groups are optionally substituted by one or more halogen atoms;
- R.sup.4 is a C.sub.1-6 straight alkyl group;
- and
- R.sup.5 is a C.sub.2-6 straight alkyl group;
- which comprises:
- reducing the imine bond of a compound of formula (II) ##STR20## wherein l, m, R, R', R.sup.4, R.sup.5 are as hereinbefore defined;
- and optionally oxidising the compound of formula (I) so obtained to the corresponding compound wherein n=1 or 2 followed by optional conversion to a salt, solvate, or physiologically functional derivative thereof.
A compound of formula (II) ##STR21## wherein l is an integer of from 0 to 4;
- m is an integer of from 0 to 5;
- R and R' are atoms or groups independently selected from halogen, nitro, phenylalkoxy, C.sub.1-4 alkoxy, C.sub.1-6 alkyl and --O(CH.sub.2).sub.p SO.sub.3 R" wherein p is an integer of from 1 to 4 and R" is hydrogen or C.sub.1-6 alkyl, wherein said phenylalkoxy, alkoxy and alkyl groups are optionally substituted by one or more halogen atoms;
- R.sup.4 is a C.sub.1-6 straight alkyl group;
- R.sup.5 is a C.sub.2-6 straight alkyl group;
- and salts, solvates and physiologically functional derivatives thereof.
Dependencies are inferred from the claim text.