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US 5,859,234 AGranted
2'-O-methyl cytidine monomer useful in oligonucleotide synthesis
AssigneeGenta Incorporated
InventorMorteza M. Vaghefi
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Abstract
Methods of preparing N.sup.4 -alkanoyl, aroyl and aralkanoyl 2'-O-methylcytidine derivatives are provided. Also provided are cytidine derivatives and nucleoside monomers comprising these cytidine derivatives which are useful in the synthesis of Oligomers, including oligonucleotides and methylphosphonate Oligomers.
Claims1
3'-diisopropylmethylphosphonamidityl-5'-dimethoxytrityl-N.sup.4 -isobutyryl-2'-O-methylcytidine.
Dependencies are inferred from the claim text.