Soluble CR1 derivatives
AssigneeAdProTech Limited
InventorsDanuta Ewa Irena Mossakowska, Ian Dodd, Anne Mary Freeman, Richard Anthony Godwin Smith
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Abstract
Soluble polypeptides are provided that comprise no more than three short consensus repeats (SCR) of Complement Receptor 1, and contain SCR3. DNA molecules encoding such soluble polypeptides, as well as methods, vectors and host cells, also are provided.
Claims14
A DNA molecule encoding a soluble polypeptide comprising no more than three short consensus repeats (SCR) of long homologous repeat A of Complement Receptor 1, wherein the DNA molecule encodes SCR3 and at least one repeat selected from the group consisting of SCR1, SCR2, and SCR4.
A DNA molecule encoding a soluble polypeptide comprising no more than one short consensus repeat (SCR) of long homologous repeat A of Complement Receptor 1, wherein the DNA molecule encodes SCR3.
A method of producing a soluble polypeptide that can inhibit complement activation, comprising:
- expressing in a host cell a DNA molecule encoding a soluble polypeptide comprising no more than three short consensus repeats (SCR) of long homologous repeat A of Complement Receptor 1, wherein the DNA molecule encodes SCR3 and at least one repeat selected from the group consisting of SCR1, SCR2, and SCR4 to produce the soluble polypeptide;
- and
- harvesting the soluble polypeptide.
A method of producing a soluble polypeptide that can inhibit complement activation, comprising:
- expressing in a host cell a DNA molecule encoding a soluble polypeptide comprising a DNA molecule encoding a soluble polypeptide comprising no more than one short consensus repeat (SCR) of long homologous repeat A of Complement Receptor 1, wherein the DNA molecule encodes SCR3.
Dependencies are inferred from the claim text.