G-beta-gamma regulated phosphatidylinositol-3' kinase

A chimeric protein comprising a p101 regulatory subunit polypeptide having the amino acid sequence shown in SEQ ID NO:2, or the amino acid sequence encoded by the cDNA contained in the cDNA clone pCMV3mycp101 as deposited with the ATCC having accession NO. 97636, fused to a heterologous polypeptide.

An isolated p101 regulatory subunit polypeptide encoded by a nucleic acid molecule having a nucleotide sequence that;

• a) encodes the amino acid sequence shown in SEQ ID NO:2 or the amino acid sequence encoded by the cDNA contained in the cDNA clone pCMV3mycp101 as deposited with the ATCC having accession No. 97636;
• or
• b) hybridizes under highly stringent conditions to the nucleotide sequence of (a) or to its complement.

A chimeric protein comprising a p101 regulatory subunit polypeptide encoded by a nucleic acid molecule having a nucleotide sequence that:

• a) encodes the amino acid sequence shown in SEQ ID NO:2 or the amino acid sequence encoded by the cDNA contained in the cDNA clone pCMV3mycp101 as deposited with the ATCC having accession No. 97636;
• or
• b) hybridizes under highly stringent conditions to the nucleotide sequence of (a) or to its complement, fused to a heterologous polypeptide.

An isolated p101 regulatory subunit polypeptide encoded by a nucleic acid molecule having a nucleotide sequence that:

• a) is the sequence shown in SEQ ID NO:1 or the cDNA contained in the cDNA clone pCMV3mycp101 as deposited with the ATCC having accession No. 97636;
• or
• b) hybridizes under highly stringent conditions to the nucleotide sequence of (a) or to its complement.

A chimeric protein comprising a p101 regulatory subunit polypeptide encoded by a nucleic acid molecule having a nucleotide sequence that:

• a) is the sequence shown in SEQ ID NO:1 or the cDNA contained in the cDNA clone pCMV3mycp101 as deposited with the ATCC having accession No. 97636;
• or
• b) hybridizes under highly stringent conditions to the nucleotide sequence of (a) or to its complement, fused to a heterologous polypeptide.

An isolated p101 regulatory subunit, or a fragment thereof, comprising an amino acid sequence selected from the group consisting of amino acid residues 1-732 of SEQ ID NO:2, amino acid residues 733-877 of SEQ ID NO:2, amino acid residues 1-160 of SEQ ID NO:2, amino acid residues 161-263 of SEQ ID NO:2, amino acid residues 161-877 of SEQ ID NO:2, and amino acid residues 1-160 and 264-877 of SEQ ID NO:2.