Neurogene
AssigneesAmgen Inc., Yeda Research and Development Co. Ltd.
InventorsLars E. Theill, Gregory S. Naeve, Yoav Citri, deceased
Life of this patent
Estimating the term…
Abstract
Disclosed are DNA and amino acid sequences for a novel polypeptide termed Neuritin which is expressed primarily in selected regions of the brain.
Claims5
An isolated neuritin polypeptide which promotes neuritogenesis in hippocampal or cortical neuronal cultures wherein said polypeptide is selected from the group consisting of:
- (a) a polypeptide having the amino acid sequence of SEQ ID NO:3;
- (b) a polypeptide having the amino acid sequence SEQ ID NO:4;
- (c) a polypeptide that is at least 70 percent identical to the polypeptide of (a) or (b) as determined by FASTA or BLAST using default opening and gap penalties and a PAM 250 scoring matrix.
An isolated neuritin polypeptide which promotes neuritogenesis in hippocampal or cortical neuronal cultures wherein said polypeptide has the amino acid sequence of SEQ ID NO:3 or a biologically active fragment thereof.
An isolated neuritin polypeptide which promotes neuritogenesis in hippocampal or cortical neuronal cultures wherein said polypeptide has the amino acid sequence of SEQ ID NO:4 or a biologically active fragment thereof.
Dependencies are inferred from the claim text.