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US 5,859,193 AGranted
Synthetic DNA derived recombinant HIV antigens
AssigneeAbbott Laboratories
InventorsSushil G. Devare, James M. Casey, Suresh M. Desai
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Abstract
The present invention provides a method of synthesizing genes encoding unique HIV-1 and HIV-2 envelope proteins and their fragments, thereby allowing overexpression of these proteins in E. coli. The HIV envelope proteins and their fragments have been expressed at high levels as individual proteins or in fusion with other proteins. The HIV envelope proteins thus expressed in E. coli can be effectively used for the detection of exposure to HIV as well as the discrimination of HIV-1 and HIV-2.
Claims7
A polypeptide of HIV-1 gp41 of the following amino acid sequence:
- MGDPMMRDNWRSELYKYKVVKIEPLGIAPTKAKRRVVQREKRADLAVGILGALFLGFLGAAGSTMGARSL TLTVQARQLLSGIVQQQNNLLRAIKDPKAQQHLLQLTVWGIKQLQARVLAVERYLKDQQLLGIWGCSGKL ICTTAVPWNASWSNKSLEDIWNNMTWMQWEREINNYTNLIYSLLEESQNQQEKNEQELLQLDKWVDASLW NWSNITKWLWYIKLFIMIVGGLAGLRIVFAVLSIVNRVRQGYSPLSFQTRLPNPRGPDRPECIDEEGGER DRDRSTRLVDISLALVWEDLRSLCLFSYHRLRDLLLIATRIVELLGRRGWEVLKYWWNLLQYVSQELKNS AVSLVNATAIAVAEGTDRVIEVWQRAYRAIRHIHRRIRQGLERILLQVHASSLESSWQPGPG.
Dependencies are inferred from the claim text.