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US 5,859,187 AGranted
Antiviral peptides
AssigneeE. R. Squibb & Sons, Inc.
InventorsJames T. Matthews, Katerina Leftheris, Robert K. Hamatake, John T. Stevens, Mary L. Haffey
Life of this patent
Estimating the term…
Abstract
Inhibition of UL42 stimulation of herpesvirus DNA polymerase activity is exhibited by novel compounds of the formulas W'--A.sub.1 --A.sub.2 --A.sub.3 --A.sub.4 --A.sub.5 --A.sub.6 --A.sub.7 --A.sub.8 --A.sub.9 --A.sub.10 --A.sub.11 --X SEQ. ID NO: 1! and Y'--A.sub.12 --A.sub.13 --A.sub.14 --A.sub.15 --A.sub.16 --A.sub.17 --Z SEQ. ID NO: 2! that are useful as antiviral agents.
Claims14
A compound having the formula
- W'--A.sub.1 --A.sub.2 --A.sub.3 --A.sub.4 --A.sub.5 --A.sub.6 --A.sub.7 --A.sub.8 --A.sub.9 --A.sub.10 --A.sub.11 --X (SEQ. ID NO:
- 1)
- wherein W' is H--, CH.sub.3 --, or CH.sub.3 CO--;
- A.sub.1 is R.sub.1, R.sub.1 -R.sub.2 or a single bond, wherein R.sub.1 and R.sub.2 are alanine;
- A.sub.2 and A.sub.8 are alanine;
- A.sub.3, A.sub.7, A.sub.9, and A.sub.10 are proline;
- A.sub.4 is glycine;
- A.sub.5 is aspartic acid;
- A.sub.6 is glutamic acid;
- A.sub.11 is tyrosine or a single bond;
- X is --OH, --NH.sub.2, or --NHCH.sub.3.
8 more elements
A compound having the formula
- Y'--A.sub.12 --A.sub.13 --A.sub.14 --A.sub.15 --A.sub.16 --A.sub.17 --Z (SEQ. ID NO:
- 2)
- wherein Y' is H--, CH.sub.3 -- or CH.sub.3 CO--, A.sub.12 is glycine-alanine-threonine-alanine or alanine-glycine-alanine-threonine-alanine;
- A.sub.13 and A.sub.14 are glutamic acid;
- A.sub.15 is threonine;
- A.sub.16 is arginine;
- A.sub.17 is arginine or a single bond;
- and Z is --OH, --NH.sub.2, or --NHCH.sub.3.
5 more elements
The compound having the formula H-Glu-Glu-Thr-Arg-Arg-Met-Leu-His-Arg-Ala-Phe-Asp-Thr-Leu-Ala-OH (SEQ. ID NO:
- 11).
Dependencies are inferred from the claim text.