Bis-sulfonamides hydroxamic acids as MMP inhibitors
AssigneePharmacia & Upjohn Company
InventorsEric Jon Jacobsen, Louis L. Skaletzky
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Abstract
The present invention provides a compound of formula I ##STR1## or pharmaceutically acceptable salts thereof wherein R.sup.1 and R.sup.2 are the same or different and are C.sub.1-10 alkyl, phenyl, hetero-aryl, or phenyl substituted with C.sub.1-4 alkyl, OR.sup.3, NHR.sup.3, CONHR.sup.3, NHCOR.sup.3, or halo; wherein R.sup.3 is H, or C.sub.1-4 alkyl; and n is 1, 2, 3, 4, 5, or 6. The compounds are inhibitors of matrix metalloproteinases involved in tissue degradation.
Claims13
A compound of formula I ##STR13## or pharmaceutically acceptable salts thereof wherein R.sup.1 and R.sup.2 are the same or different and are
- a) C.sub.1-10 alkyl,
- b) phenyl,
- c) hetero-aryl, or
- d) phenyl substituted with C.sub.1-4 alkyl, OR.sup.3, NHR.sup.3, CONHR.sup.3, NHCOR.sup.3, SO.sub.2 NHR.sup.3, or halo;
- R.sup.3 is
- a) H, or
- b) C.sub.1-4 alkyl;
- and
- n is 1, 2, 3, 4, 5, or 6.
Dependencies are inferred from the claim text.