Leukotriene B4 derivatives, process for their production and their use as pharmaceutical agents

A leukotriene-B.sub.4 of formula I, ##STR18## in which R.sub.1 represents CH.sub.2 OH, CH.sub.3, CF.sub.3, COOR.sub.4, or CONR.sub.5 R.sub.6,

• R.sub.2 represents H or an aryl or sulfonyl group of a carboxylic or sulfonic acid with 1-15 C atoms,
• R.sub.3 symbolizes H;
• C.sub.1 -C.sub.14 alkyl or C.sub.2 -C.sub.14 alkenyl, each optionally substituted with halogen or phenyl optionally substituted as described below for C.sub.6 -C.sub.10 aryl;
• C.sub.3 -C.sub.10 cycloalkyl, optionally substituted with alkyl or halogen;
• C.sub.6 -C.sub.10 aryl, optionally substituted with halogen, phenyl, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, fluoromethyl, chloromethyl, trifluoromethyl, carboxyl or hydroxy;
• or a 5- to 6-membered aromatic heterocyclic ring with at least 1 heteroatom,
• R.sub.4 means hydrogen;
• C.sub.1 -C.sub.10 alkyl, optionally substituted with halogen, alkoxy, C.sub.6-10 -aryl, C.sub.6-10 -aroyl, di-C.sub.1-4 -alkylamino or tri-C.sub.1-4 -alkylamino, the aryl and aryl groups being optionally substituted as described above for C.sub.6-10 aryl for R.sub.3 ;
• C.sub.3 -C.sub.10 cycloalkyl optionally substituted with C.sub.1-4 alkyl;
• C.sub.6 -C.sub.10 aryl optionally substituted by halogen, phenyl, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, fluoromethyl, chloromethyl, trifluoromethyl, carboxyl or hydroxy;
• CH.sub.2 --CO--(C.sub.6 -C.sub.10) aryl, wherein the C.sub.6 -C.sub.10 -aryl group is optionally substituted as described above under R.sub.3 ;
• or a 5- to 6-membered ring with at least 1 heteroatom,
• A symbolizes a trans, trans--CH.dbd.CH--CH.dbd.CH, a --CH.sub.2 CH.sub.2 --CH.dbd.CH-- or a tetramethylene group,
• B symbolizes a C.sub.1 -C.sub.10 straight-chain or branched-chain alkylene group, which optionally can be substituted by fluorine or the group ##STR19## D means a direct bond, oxygen, sulfur, --C.tbd.C--, --CH.dbd.CR.sub.7, or together with B can also mean a direct bond,
• R.sub.5 and R.sub.6 are the same or different, and represent H or C.sub.1 -C.sub.4 alkyl or R.sub.6 represents H and R.sub.5 represents a C.sub.1 -C.sub.15 aryl or sulfoyl group of a carboxylic or sulfonic acid, and are optionally substituted with OH,
• R.sub.7 means H, C.sub.1 -C.sub.5 alkyl, chlorine, or bromine,
• n is 2-5, and, if R.sub.4 means hydrogen, a salt thereof with a physiologically compatible base, or a cyclodextrin clathrate therof.