Acetylsalicylic acid nitrates
AssigneeBayer Aktiengesellschaft
InventorsEva Lesur, Dieter Neuser, Oswald Lockhoff, Elisabeth Perzborn, Peter Kurka, Johannes Peter Stasch
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Abstract
The invention relates to new derivatives of acetylsalicylic acid (called ASA in the following), which contain an NO.sub.3 structure. They are therapeutically active either as the intact active compound molecule or after cleavage (NO release). The invention also relates to processes for their preparation and their use as medicaments, in particular for the alleviation of pain, inhibition of platelet aggregation, lowering of fever and for the prevention of cardiovascular disorders and oncoses.
Claims5
Compounds of the general formula (I) ##STR7## in which A represents O or NH,
- X represents (CHZ).sub.m --CH.sub.2 --Z,
- Y represents H or (CHZ).sub.n --CH.sub.2 --Z, or
- X and Y together represent --(CHZ).sub.p --, where
- Z represents H, OH and/or ONO.sub.2,
- m represents a number from 1 to 4,
- n represents a number from 0 to 3, and
- p represents a number from 2 to 6,
- with the proviso that in the compounds according to the invention at least two of the substituents Z represent ONO.sub.2 or else ONO.sub.2 in combination with OH.
Dependencies are inferred from the claim text.