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US 5,859,048 AGranted
Pharmaceutics for mucosal administration
AssigneeTeikoku Hormone Mfg. Co., Ltd.
InventorsMasami Oohashi, Noriaki Uchida, Junichi Sakata, Masaru Sunamoto
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AssigneeTeikoku Hormone Mfg. Co., Ltd.
InventorsMasami Oohashi, Noriaki Uchida, Junichi Sakata, Masaru Sunamoto
Estimating the term…
In pharmaceutics for mucosal administration containing pharmacologically active peptides or proteins and tolmetin or salts thereof exhibited very excellent effect as mucosal absorption enhancers. Furthermore, when the pharmaceutics for mucosal administration are for rectal administration, the suppository in which at least either the active ingredient, peptide or protein, or the mucosal absorption enhancer is converted to a complex with a high molecular compound dissolving in water at pH 5 or higher and together uniformly dispersed in a fatty suppository base exhibited markedly improved rectal absorbability compared with that of conventional pharmaceutics for rectal administration and at the same time increased stability of the peptide or protein which is the active ingredient.
Pharmaceutics for mucosal administration characterized by containing (A) pharmacologically active peptide or proteins and tolmetin or a salt thereof as a mucosal absorption enhancer.
Pharmaceutics for rectal administration characterized by containing (A) pharmacologically active peptide or protein and (B) a mucosal absorption enhancer, in which at least either of (A) the peptide or protein and (B) the mucosal absorption enhancer has been converted into a form of a complex with (C) a high molecular compound which is water soluble at pH 5 of higher, and both (A) the peptide or protein and (B) the mucosal absorption enhancer are uniformly dispersed in a fatty suppository base.
Pharmaceutics for rectal administration characterized by containing (A) pharmacologically active peptide or protein and (B) a mucosal absorption enhancer, in which at least either of (A) the peptide or protein and (B) the mucosal absorption enhancer has been converted into a form of a complex with (C) a high molecular compound which is water-soluble at pH 5 or higher, and both (A) the peptide or protein and (B) the mucosal absorption enhancer are uniformly dispersed in a fatty suppository base, and wherein (C) the high molecular compound is methacrylic acid copolymer L, carboxymethylethyl cellulose, hydroxypropylmethyl cellulose phthalate or hydroxypropylmethyl cellulose acetate succinate.
Dependencies are inferred from the claim text.