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US 5,859,036 AGranted
3,4-diarylthiazolin-2-one or -2-thione derivatives, their methods of preparation and their uses in their methods of preparation and their uses in therapeutics
AssigneeLaboratories UPSA
InventorsEric Sartori, Jean-Marie Teulon
Life of this patent
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Abstract
The present invention relates to derivatives of formula ##STR1## and to their use in therapeutics especially as drugs with anti-inflammatory and analgesic properties.
Claims14
3,4-diarylthiazolin-2-one or 2-thione compounds of the formula (I):
- ##STR15## in which:
- R represents:
- a lower alkyl radical having 1 to 6 carbon atoms,
- a lower haloalkyl radical having 1 to 6 carbon atoms, or
- an --NH.sub..sub.2 group,
- R.sub.1 represents:
- a hydrogen atom,
- a lower alkyl radical having 1 to 6 carbon atoms, or
- a lower haloalkyl radical having 1 to 6 carbon atoms,
- X represents:
- an oxygen atom, or
- a sulphur atom,
- X.sub.1 and X.sub.2 independently represent:
- a hydrogen atom,
- a halogen atom,
- a lower alkyl radical having 1 to 6 carbon atoms,
- a lower haloalkyl radical having 1 to 6 carbon atoms,
- a lower O-alkyl radical having 1 to 6 carbon atoms, or
- an NR.sub.2 R.sub.3 radical in which R.sub.2 and R.sub.3 independently represent a lower alkyl radical having 1 to 6 carbon atoms,
- or even X.sub.1 and X.sub.2 together can form a methylene dioxy group, as well as their addition salts.
17 more elements
Dependencies are inferred from the claim text.