Quinoline carboxylic acid
AssigneeHokuriku Seiyaku Co., Ltd.
InventorsYasuo Ito, Hideo Kato, Shingo Yasuda, Noriyuki Kada, Toshihiko Yoshida, Yoichi Yamamoto
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Abstract
5-Amino-7-((3S,4S)-3-amino-4-methyl (or ethyl)-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methyl-4-oxoqu inoline-3-carboxylic acid or a pharmacologically acceptable salt thereof represented by the following formula wherein asymmetric carbon atoms marked with asterisks are in the S-configurations and R.sup.1 represents methyl group or ethyl group; and an antibacterial agent comprising said compound as an active ingredient. ##STR1##
Claims6
A compound or a salt thereof represented by the following formula (I):
- ##STR10## wherein asymmetric carbon atoms marked with asterisks are in the S-configurations, and R.sup.1 represents methyl group or ethyl group.
5-Amino-7-((3S,4S)-3-amino-4-methyl-1-pyrrolidinyl)-1-cyclopropyl-6 -fluoro-1,4-dihydro-8-methyl-4-oxoquinoline-3-carboxylic acid or a salt thereof.
A compound represented by the following formula (II):
- ##STR11## wherein the asymmetric carbon atoms marked with asterisks are in the S-configurations;
- R.sup.1 represents methyl group or ethyl group;
- R.sup.2 represents a hydrogen atom, a lower alkyl group, or BF.sub.2 group;
- and R.sup.3 and R.sup.4 independently represent a hydrogen atom or an amino protective group;
- with the proviso that R.sup.2, R.sup.3, and R.sup.4 are not simultaneously hydrogen atoms.
A pharmaceutical composition comprising a compound or a pharmacologically acceptable salt thereof represented by the following formula (I):
- ##STR12## wherein asymmetric carbon atoms marked with asterisks are in the S-configurations, and R.sup.1 represents methyl group or ethyl group.
An antibacterial method comprising administering a compound or a pharmacologically acceptable salt thereof represented by the following formula (I):
- ##STR13## wherein asymmetric carbon atoms marked with asterisks are in the S-configurations, and R.sup.1 represents methyl group or ethyl group.
An organic synthesis method comprising converting a compound represented by the following formula (I), wherein asymmetric carbon atoms marked with asterisks are in the S-configurations, and R.sup.1 represents methyl group or ethyl group:
- ##STR14## into a compound represented by the following formula (II):
- ##STR15## wherein asymmetric carbon atoms marked with asterisks are in the S-configurations;
- R.sup.1 represents methyl group or ethyl group;
- R.sup.2 represents a hydrogen atom, a lower alkyl group, or a BF.sub.2 group;
- and R.sup.3 and R.sup.4 independently represent a hydrogen atom or an amino protective group;
- with the proviso that R.sup.2, R.sup.3, and R.sup.4 are not simultaneously hydrogen atoms.
Dependencies are inferred from the claim text.