Methods for protecting against cardiac ischemia by administering adenosine A.sub.2a receptor antagonists
AssigneesThe Trustees of the University of Pennsylvania, National Institute of Health
InventorsBruce T. Liang, Kenneth A. Jacobson
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Abstract
Methods for reducing or preventing ischemic damage of the heart are disclosed. A preferred embodiment of the invention comprises the administration of a specific A.sub.2a receptor antagonist, 8-(3-chlorostyryl) caffeine, to patients suffering from ischemic damage or at risk for the same.
Claims20
A method for preventing or reducing ischemic damage to heart muscle cells in a patient in need of such treatment or at risk for said ischemic damage, comprising administering to said patient an antagonist to an A2a receptor in an amount effective to inhibit A2a receptor activation in the heart of said patient without activation of an A3 adenosine receptor.
A method for treating a patient to enhance myocardial responsiveness of heart muscle cells to preconditioning stimuli, comprising administering to a patient in need of said treatment, an A2a receptor antagonist in an amount effective to enhance myocardial response to said preconditioning stimuli, without activation of an A3 adenosine receptor.
Dependencies are inferred from the claim text.