Memory enhancing and anti-dementia agent containing dehydroevodiamine HC1 as active ingredient
AssigneesJE IL Pharmaceutical Co., Ltd., Yoo-Hun Suh
InventorsYoo-Hun Suh, Sam-Sik Kang, Seong-Hun Kim, Cheol-Hyoung Park, Woong Choi
Life of this patent
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Abstract
Dehydroevodiamine-HCl, a constituent of Evodia rutaecarpa Benth. (DHED) exhibits anti-AChE activity and improves the memory impairment of animals produced by scopolamine in the passive avoidance test. Thus, DHED can be a potent, long term memory enhancing and anti-dementia agent if it is used together with a pharmaceutically acceptable carrier.
Claims23
A method for treating dementia in a patient, comprising:
- administering an effective amount of an anti-dementia agent to the patient, wherein the anti-dementia agent includes a pharmaceutically acceptable carrier and dehydroevodiamine-HCl expressed by formula (I) as an active ingredient, wherein formula (I) is as follows:
- ##STR3##
A method for inhibiting acetylcholinesterase activity, comprising:
- administering an effective amount of a pharmaceutical composition to a patient to inhibit acetylcholinesterase activity, wherein the pharmaceutical composition includes a pharmaceutically acceptable carrier and dehydroevodiamine-HCl expressed by formula (I) as an active ingredient, wherein formula (I) is as follows:
- ##STR4##
A method for treating amnesia in a patient, comprising:
- administering an effective amount of a pharmaceutical composition to the patient, wherein the pharmaceutical composition includes a pharmaceutically acceptable carrier and dehydroevodiamine-HCl expressed by formula (I) as an active ingredient, wherein formula (I) is as follows:
- ##STR5##
A method for enhancing memory in a patient, comprising:
- administering an elective amount of a pharmaceutical composition to the patient to enhance the memory, wherein the pharmaceutical composition includes a pharmaceutically acceptable carrier and dehydroevodiamine-HCl expressed by formula (I) as an active ingredient, wherein formula (I) is as follows:
- ##STR6##
Dependencies are inferred from the claim text.