Dihydropyridine derivatives as bradykinin antagonist

A compound of the formula:

• ##STR9## and its pharmaceutically acceptable salts, wherein A.sup.1 and A.sup.2 are each halo;
• X is a direct bond, CH.sub.2, CO, O, S, S(O) or S(O).sub.2 ;
• R.sup.1 is selected from the following:
• (a) hydrogen, C.sub.1-4 alkyl optionally substituted with one or two substituents selected from hydroxy, amino, C.sub.1-4 alkylamino, di-C.sub.1-4 alkylamino, pyridyl, carbamoyl, pyrrolidinocarbonyl, propylaminocarbonyl, piperidinocarbonyl or morpholinocarbonyl;
• (b) piperidinyl optionally substituted on the nitrogen atom with C.sub.1-4 alkyl or C.sub.1-4 alkoxycarbonyl;
• (c) C.sub.5-14 cycloalkyl, bicycloalkyl or tricycloalkyl, optionally substituted with one or two substituents selected from oxo, hydroxy, amino, C.sub.1-4 alkylamino, di-C.sub.1-4 alkylamino, methoxybenzamido or morpholino;
• (d) C.sub.7-14 azacyclo-, azabicyclo- or azatricyclo-alkyl, in which the nitrogen atom optionally has a substituent selected from C.sub.1-4 alkyl, benzyl optionally substituted with one or two substituents selected from halo and trihalo C.sub.1-4 alkyl, C.sub.1-4 alkyloxycarbonyl optionally substituted with one or two halogen atoms and C.sub.2-5 acyl;
• and
• (e) C.sub.7-10 bicycloalkenyl, benzo C.sub.5-7 cycloalkyl or heterocyclic selected from a monocyclic or bicyclic hydrocarbon group having 4 to 10 carbon atoms and 1 to 3 hetero atoms;
• R.sup.2 is hydrogen, C.sub.1-4 alkyl, phenyl optionally substituted with one or two substituents selected from halo, C.sub.1-4 alkyl, trihalo C.sub.1-4 alkyl and C.sub.1-4 alkoxy, or heterocyclic selected from a monocyclic or bicyclic hydrocarbon group having 4 to 10 carbon atoms and 1 to 3 hetero atoms;
• selected from a monocyclic or bicyclic hydrocarbon group having 4 to 10 carbon atoms and 1 to 3 hetero atoms;
• and
• R.sup.3 and R.sup.4 are each C.sub.1-3 alkyl.