CCK or gastrin modulating benzo ›b!›1,4! diazepines derivatives

Benzo›b!›1,4!diazepine compounds of the following formula (I):

• ##STR21## wherein:
• R.sup.1 is selected from the group consisting of C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.7 cycloalkyl, phenyl, or phenyl mono-, di-, or trisubstituted independently with hydroxy, C.sub.1-6 alkyl, C.sub.1-6 alkyl substituted with 1-8 fluorine atoms, C.sub.1-6 alkoxy, C.sub.1-6 alkoxy substituted with 1-8 fluorine atoms, carboxyC.sub.1-6 alkoxy, halo, amino, mono- or di(C.sub.1-6 alkyl)amino, --COO(C.sub.1-4 alkyl), C.sub.1-4 alkylthio, carboxymethylthio, trifluoromethyl-sulfonylamino, phenylC.sub.1-6 alkoxy;
• R.sup.2 is selected from the group consisting of C.sub.3 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.3 -C.sub.6 alkenyl, benzyl, phenylC.sub.1 -C.sub.3 alkyl, phenyl mono-, di-, or trisubstituted independently in the ortho or para positions with hydroxy, C.sub.1-4 alkyl, C.sub.1-6 alkoxy, cyano, benzyloxy, pyrrolidino, morpholino, carboxyC.sub.1-6 alkoxy, halo, amino, mono- or di(C.sub.1-6 alkyl)amino, --COO(C.sub.1-4 alkyl), C.sub.1-4 alkylthio, carboxymethylthio, trifluoromethylsulfonylamino, phenylC.sub.1-6 alkoxy, C.sub.1-4 alkylsulfonyl or C.sub.1-4 alkylsulfinyl substituents or partially aromatic bicycloheteroaryl;
• or
• NR.sup.1 R.sup.2 together form 1,2,3,4-tetrahydroquinoline or benzazepine, mono-, di-, or trisubstituted independently with C.sub.1-6 alkyl, C.sub.1-6 alkoxy or halogen substituents;
• p is an integer 0 or 1;
• q is an integer 0 or 1;
• r is an integer 0 or 1;
• t is an integer 0 or 1, provided that when r is 0 then t is 0;
• R.sup.3, R.sup.5 and R.sup.6 are independently hydrogen or C.sub.1-6 alkyl;
• R.sup.4 is C.sub.1-6 alkylene or C.sub.2-6 alkenylene;
• R.sup.7 is selected from the group consisting of hydrogen, C.sub.1-6 alkyl, C.sub.1-6 cycloalkyl, phenyl, phenyl mono-, di-, or trisubstituted independently with C.sub.1-4 alkyl, hydroxy, C.sub.1-6 alkoxy, halogen, amino, mono- or di(C.sub.1-6 alkyl)amino, nitro, carboxy, --COO(C.sub.1-4 alkyl), carboxyC.sub.1-6 alkoxy, carboxyC.sub.1-4 alkyl, carboxymethylthio, heteroaryl, mono- or di(C.sub.1-6 alkyl)aminoalkyl, or trifluoromethyl, trifluoromethoxy, C.sub.1-4 alkylthio, --SO.sub.v (C.sub.1-4 alkyl), --SO.sub.v NH(C.sub.1-4 alkyl), --SO.sub.v CF.sub.3 or --SO.sub.v C.sub.6 H.sub.5, --(CH.sub.2).sub.v NO.sub.2, --(CH.sub.2).sub.v CN, --(CH.sub.2).sub.v COOH, --(CH.sub.2).sub.v COO(C.sub.1-4 alkyl), --(CH.sub.2).sub.v SCH.sub.3, --(CH.sub.2).sub.v SOCH.sub.3, --(CH.sub.2).sub.v SO.sub.2 CH.sub.3, --(CH.sub.2).sub.v CONH.sub.2, --SCH.sub.2 COOH, --CONH(SO.sub.2 CH.sub.3), --CONH(SO.sub.2 CF.sub.3), --(CH.sub.2).sub.v N(C.sub.1-4 alkyl).sub.2, --(CH.sub.2).sub.v NH(SO.sub.2 CF.sub.3), --(CH.sub.2).sub.v N(SO.sub.2 CF.sub.3)(C.sub.1-4 alkyl), --(CH.sub.2).sub.v SO.sub.2 NHCO(C.sub.1-4 alkyl), --(CH.sub.2).sub.v SO.sub.2 N(C.sub.1-4 alkyl)CO(C.sub.1-4 alkyl), --(CH.sub.2).sub.v CONHSO.sub.2 (C.sub.1-4 alkyl), --(CH.sub.2).sub.v CON(C.sub.1-4 alkyl)SO.sub.2 (C.sub.1-4 alkyl), --(CH.sub.2).sub.v NHR.sup.10 or --(CH.sub.2).sub.v OR.sup.11 substituents, benzyloxy, heteroaryl, heteroaryl mono- or disubstituted independently with halogen, C.sub.1-6 alkyl, hydroxy, nitro, cyano, carboxy, C.sub.1-6 alkoxy, benzyloxy, --COO(C.sub.1-4 alkyl), amino, mono- or di(C.sub.1-6 alkyl)amino, phenyl or benzyl substituents, napthyl, bicycloheteroaryl, bicycloheteroaryl substituted independently with hydroxy, halogen, carboxyalkyl, acetyl, phenyl, heteroaryl, C.sub.1-4 alkoxy or cyano substituents, or partially aromatic bicycloheteroaryl, provided that when R.sup.7 is oxadiazole then R.sup.8 is not hydrogen, further provided when p is 1, q is 0, r is 0 and t is 0 then bicycloheteroaryl and substituted bicycloheteroaryl are not 2-indolyl or substituted 2-indolyl, still further provided that when p is 0, q is 1, r is 1 and t is 0 then indolyl and substituted indolyl are bound at the 2 position, even still further provided that when n, p and q are 1 and r is 0 then R.sup.7 is not indolyl;
• R.sup.10 is hydrogen, C.sub.1-4 alkyl, benzyl, --SO.sub.3 H, --SO.sub.2 CH.sub.3, --SO.sub.2 CF.sub.3, --SO.sub.2 C.sub.6 H.sub.5, --COO(C.sub.4 H.sub.9) or --COO(CH.sub.2 C.sub.6 H.sub.5);
• R.sup.11 is hydrogen, C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, --CH.sub.2 C.sub.6 H.sub.5, --CH.sub.2 COOH, --CH.sub.2 CONH.sub.2, --CH.sub.2 CONH(C.sub.1-4 alkyl), --CH.sub.2 CON(C.sub.1-4 alkyl).sub.2 or ##STR22## v is an integer selected from the group of 0, 1 or 2;
• or NR.sup.6 R.sup.7 together form a saturated 5, 6, or 7 membered ring optionally interrupted by 1,2,3 or 4N, S or O heteroatoms, with the proviso that any two O or S atoms are not bonded to each other;
• w is an integer selected from the group of 0, 1 or 2;
• R.sup.8 is selected from the group consisting of hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.1-6 alkoxyC.sub.1-6 alkyl, carboxyC.sub.1-6 alkyl, halogen, amino, cyano, aminoC.sub.1 -C.sub.6 alkyl, mono- or di(C.sub.1-6 alkyl)amino, C.sub.1 -C.sub.6 alkylamino(C.sub.1 -C.sub.6 alkyl), mono- or di(C.sub.1-6 alkyl)aminoamino, C.sub.1-6 alkylmorpholino, C.sub.1-6 alkylpiperidino, C.sub.1-6 alkyltetrahydropyrrolyl, C.sub.1-6 alkylthio, C.sub.1-6 alkylthioC.sub.1-6 alkyl or C.sub.1-4 alkyoxycarbonylC.sub.1-4 alkyl, provided that when R.sup.4 is ethyl then R.sup.8 is not ethyl;
• m is an integer selected from the group of 0, 1, 2, 3 or 4;
• R.sup.9 is selected from the group consisting of hydrogen, C.sub.1 -C.sub.6 alkyl, phenyl or phenyl mono- or disubstituted independently with halogen substituents, or a heteroaryl selected from the group consisting of pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, furanyl, thiophenyl, pyrrolyl, oxazolyl, thiazolyl, imidazolyl, pyrazolyl, isoxazolyl, isothiazolyl, oxadiazolyl, thiazolyl, thiadiazolyl, pyrrolidinyl, piperidinyl, morpholinyl or thiomorpholinyl, where such heteroaryl may be mono- or di-ortho-substituted independently with halogen, C.sub.1-4 alkyl, nitro, carboxyl, C.sub.1-4 alkoxycarbonyl, C.sub.1-4 alkoxy, C.sub.1-4 alkylthio, amino or mono- or di(C.sub.1-6 alkyl)amino substituents;
• Y and Z are independently hydrogen or halogen;
• or a pharmaceutically acceptable acid-addition or base-addition salt thereof.