Salts of azelastine having improved solubility
AssigneeAsta Pharma Aktiengesellschaft
InventorsHelmut Hettche, Reinhard Muckenschnabel, Gerhard Scheffler, Ilona Fleischhauer, Wolfgang Morick
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Abstract
The present invention relates to salts of azelastine having improved solubility in water. The salts of the present invention are prepared by reacting azelastine with acetic acid, gluconic acid, lactic acid or malic acid. A pharmaceutical composition may be prepared containing an azelastine salt and a pharmaceutically-acceptable carrier or diluent therefor. The pharmaceutical composition is useful in the treatment of allergies, asthma, inflammatory and psoriasis disorders and provides a cytoprotective effect.
Claims6
A pharmaceutical composition in the form of an aqueous solution useful for the prophylaxis and treatment of allergy and asthma, comprising:
- a salt of azelastine selected from a member of the group consisting of azelastine acetate, azelastine gluconate, azelastine lactate and azelastine malate, wherein when the salt is azelastine acetate the solubility of the salt in aqueous solution is at least about 2%, when the salt is azelastine malate or azelastine lactate the solubility of the salt in aqueous solution is at least about 3%, and when the salt is azelastine gluconate the solubility of the salt in aqueous solution is at least about 5%, and wherein the salt is present in an amount effective for the treatment and prophylaxis of allergy and asthma,
- and a member of the group consisting of pharmaceutically-acceptable carriers and diluents therefor.
Dependencies are inferred from the claim text.