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US 5,859,001 AGranted
Neuroprotective effects of polycyclic phenolic compounds
AssigneesUniversity of Florida Research Foundation, Inc., Apollo Genetics
InventorsJames W Simpkins, Katherine Gordon, Pattie S. Green
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Abstract
This application relates to the use of non-estrogen compounds having a terminal phenol group in a four-ring cyclopentanophenanthrene compound structure for conferring neuroprotection to cells and for the treatment of neurodegenerative diseases.
Claims8
A method for conferring neuroprotection on a population of cells in a subject, the method comprising:
- (i) providing a non-estrogen compound having a terminal phenol group in a four-ring cyclopentanophenanthrene structure, the compound having a molecular weight of less than 1000 Daltons;
- and
- (ii) administering the compound in an effective dose to the population of cells so as to confer neuroprotection.
A method of treating a neurodegenerative disease by conferring neuroprotection in a subject, the method comprising:
- (a) preparing an effective dose of a formulation to achieve a plasma concentration of less than 500 nM the formulation containing a non-estrogen compound having a terminal phenol in a four-ring cyclopentanophenanthrene structure, the compound having a molecular weight less than 1000 Daltons;
- and
- (b) administering the dose to the subject.
Dependencies are inferred from the claim text.