Pharmaceutical compositions containing calcitonin gene-related peptide (CGRP) and use thereof to ameliorate hyperimmune mediated diseases and abnormal conditions
AssigneeYale University
InventorAgnes Marie-Claude Vignery
Life of this patent
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Abstract
Calcitonin gene-related peptide and calcitonin regulate immune cell function and cytokine release and are useful in the treatment of immune cell and cytokine mediated, immune mediated diseases, such as rheumatoid arthritis, treating viral infections, tumors and organ transplants.
Claims7
A method of down-regulating the immune response via cytokine release and receptor expression by immune and non-immune cells, interleukin-1 (IL-1) release or IL-1 and interleukin-2 (IL-2) release from interleukin-1 and interleukin-2 releasing cells in a living mammal which comprises administering thereto an immunosuppressive amount of calcitonin gene-related peptide (CGRP).
A pharmaceutical composition adapted for noningestion systemic administration which comprises per unit dosage an IL-1 release-inhibiting amount of CGRP in admixture with a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.