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US 5,858,974 AGranted
Anti-fungal peptides
AssigneeXoma Corporation
InventorsRoger G. Little, II, Edward Lim, Mitchell B. Fadem
Life of this patent
Estimating the term…
Abstract
The present invention relates generally to anti-fungal peptides derived from or based on Domain III (amino aids 142-169) of bactericidal/permeability-increasing protein (BPI) and in vivo or in vitro uses of such peptides.
Claims15
A peptide which has an amino acid sequence of human bactericidal/permeability-increasing protein (BPI) from about position 148 to about position 161 of SEQ ID NO:
- 251 and variants of the sequence having antifungal activity.
An antifungal peptide having from six to fourteen amino acids comprising:
- (a) a core sequence of amino acids selected from the group consisting of LIQL, IQLF, WLIQL, LIQLF, and WLIQLF;
- and
- (b) one or more cationic amino acids selected from the group consisting of K, R, H, ornithine and diaminobutyric acid at the amino and/or carboxy terminal portion of the core sequence.
Dependencies are inferred from the claim text.