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US 5,858,970 AGranted
Polypeptide having Factor Xa inhibitory activity
AssigneeBio-Technology General Corp.
InventorsElisha P. Zeelon, Moshe M. Werber, Avigdor Levanon
Life of this patent
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Abstract
A novel polypeptide derived from the leech Hirudo medicinalis was found to be able to inhibit Factor Xa thereby reducing the extent of blood coagulation. The polypeptide is useful in treating conditions of excessive blood coagulation. A recombinant organism containing cDNA encoding the polypeptide has been deposited in the ATCC under Accession No. 69134. Recombinant microorganisms able to produce the polypeptide have been deposited in the ATCC under Accession Nos. 69135, 69137 and 69269.
Claims9
A polypeptide comprising the amino acid sequence ##STR20## wherein X is MET or absent;
- Y is 0-29 amino acids of the sequence LYS MET CYS TRP ASN LYS GLY CYS PRO CYS GLY GLN ARG CYS ASN LEU HIS ARG ASN GLU CYS GLU VAL ILE ALA GLU ASN ILE GLU, with the proviso that if Y is more than 0 amino acids then the carboxy-terminal Glu of Y is present and wherein Val.sup.24 may be preceded by Gly;
- and Z is absent or all or a part of the sequence Pro.sup.110 -Lys.sup.156 shown in FIG. 7 (SEQ ID NO. 24), with the proviso that if Z is more than 0 amino acids then the amino-terminal Pro of Z is present.
Dependencies are inferred from the claim text.