Appetite supression factor and related methods
AssigneesUniversity of Washington, ZymoGenetics, Inc.
InventorsDavid S. Weigle, Joseph L. Kuijper, John W. Forstrom
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Abstract
Methods for identifying factors that regulate appetite are disclosed. Preferably, the methods feature determinination of decreased food consumption in selected recipient mammals following administration of a test sample. A product having appetite suppressing activity is also described. In addition, methods for reducing food consumption in a mammal, featuring administration of a pharmaceutical composition comprising a representative appetite suppression factor, are disclosed.
Claims14
A method for inhibiting food consumption in a mammal, comprising administering an effective dose of a composition comprising an appetite suppression factor expressed by adipose tissue, wherein the factor is between about 14 kDa and 16 kDa in size as determined by SDS polyacrylamide gel electrophoresis under reducing conditions.
A method for inhibiting food consumption in a mammal, comprising administering an effective dose of a composition comprising an appetite suppression factor expressed by adipose tissue, wherein the factor is ob protein.
Dependencies are inferred from the claim text.