Treatment of contact lenses with aqueous solution including phosphonic compounds
AssigneeBausch & Lomb Incorporated
InventorsWanda G. Richard, David J. Heiler
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Abstract
The present invention provides non-oxidative methods for treating contact lenses and compositions for the same. The present invention includes contacting a lens with an aqueous solution comprising a phosphonic acid compound. In preferred embodiments of the invention, the subject phosphonic compounds are used in combination with antimicrobial agents for providing simultaneous disinfection and cleaning of contact lenses including the prevention or removal of protein deposits.
Claims20
A non-oxidative method for treating contact lenses comprising contacting a lens with an ophthalmically safe aqueous solution comprising a phosphonic acid compound, or a physiologically compatible salt thereof, represented by the formula:
- ##STR5## wherein Z is a connecting radical equal in valence to n, wherein n is an integer from 1 to 6, and containing 1 to 12 carbon atoms, and wherein Z is selected from the group consisting of unsubstituted or substituted saturated hydrocarbon radicals and amine-containing radicals, which amine-containing radicals are saturated hydrocarbon radicals in which the carbon atoms are interrupted with at least one nitrogen atom that forms a secondary or tertiary amine and in which the number of carbon atoms in the amine-containing radical is at least n+1, and said substituted saturated hydrocarbon radicals may be substituted with halogen, hydroxy, amine, carboxy, alkylcarbonyl, alkoxycarbonyl and/or substituted or unsubstituted phenyl, and wherein the substituted phenyl may be substituted with halogen, hydroxy, amine, carboxy, alkylcarbonyl, and/or alkyl, and wherein said alkyl or alkoxy groups have 1 to 4 carbon atoms.
A non-oxidative method for treating contact lenses comprising contacting a lens with an aqueous solution comprising a phosphonic compound represented by the formula:
- ##STR7## wherein each of a, b, c, and d are independently selected from integers from 0 to 4, and physiologically compatible salts of such phosphonic compounds.
An ophthalmically safe non-oxidative aqueous solution having a buffered pH of from about 5 to about 8 and an osmolality of 200 to 450 mOsm/kg for treating contact lenses comprising:
- a phosphonic compound represented by the formula:
- ##STR8## wherein Z is a connecting radical equal in valence to n, wherein n is an integer from 1 to 6, and containing 1 to 12 carbon atoms, and wherein Z is selected from the group consisting of unsubstituted or substituted saturated hydrocarbon radicals and amine-containing radicals, which amine-containing radicals are saturated hydrocarbon radicals in which the carbon atoms are interrupted with at least one nitrogen atom that forms a secondary or tertiary amine and in which the number of carbon atoms in the amine-containing radical is at least n+1, wherein said substituted saturated hydrocarbon radicals may be substituted with halogen, hydroxy, amine, carboxy, alkylcarbonyl, alkoxycarbonyl and/or substituted or unsubstituted phenyl, wherein the substituted phenyl may be substituted with halogen, hydroxy, amine, carboxy and/or alkyl, and wherein said alkyl or alkoxy has 1 to 4 carbon atoms, and an effective amount of at least one non-oxidative antimicrobial agent for a contact-lens treating solution.
A non-oxidative aqueous solution for treating contact lenses comprising:
- a phosphonic compound represented by the formula:
- ##STR10## wherein each of a, b, c, and d are independently selected from integers from 0 to 4, and physiologically compatible salts of said phosphonic compounds and further comprising a disinfecting amount of a bactericide selected from the group consisting of biguanides and polymeric quaternary ammonium and salts thereof.
A non-oxidative method for cleaning and disinfecting a contact lenses with a multi-purpose solution comprising
- (a) contacting a contact lens with an ophthalmically safe solution comprising about 0.005 to 1.0 percent weight by volume of at least one phosphonic acid compound, or a physiologically compatible salt thereof, wherein the compound has at least one phosphonic acid group and 1 to 12 carbon atoms;
- and
- (b) placing the treated contact lens in the eyes of the wearer.
A method of disinfecting or cleaning and disinfecting a soft contact lens with a multi-purpose solution, which method comprises:
- (a) soaking the lens in an ophthalmically safe solution, such that disinfection of the contact lens is obtained within a minimum recommended soaking period, the solution comprising, in formulation, the following components:
- (i) 0.005 to 1.0 percent weight by volume of at least one phosphonic acid compound, or its physiologically compatible salt, which compound has at least one phosphonic acid group and 1 to 12 carbon atoms;
- (ii) an effective amount of a surfactant,
- (iii) an effective amount of a non-oxidative germicide, and
- (iv) an effective amount of buffering and tonicity agents, and
- (b) directly placing the treated lens on the eye of the wearer, such that (ii) rinsing with a different solution prior to placement on the eye is not required, and (iii) no other solution is required for daily cleaning of the lens.
Dependencies are inferred from the claim text.